Photon-Scanning Approach to Control Spiral Wave Dynamics in the Heart.

Self-organizing spiral electrical waves are produced in the heart during fatal cardiac arrhythmias. Controlling these waves is therefore an essential step in managing the disease. Here we present an effective method for controlling cardiac spiral waves using optogenetics.

Dataset on developing low glycemic index rice variety suitable for irrigated ecosystem in Bangladesh.

This dataset offers a comprehensive analysis of rice grain yield and quality traits over a period of three years, spanning 27 different environments in Bangladesh. The focus is on evaluating the performance of various genotypes (G), environments (E), and their interactions (GEI). The study's goal is to identify a stable and adaptive rice genotype that not only exhibits high-quality traits but also has a low glycemic index.

Hydrogeochemical appraisal, sources, quality and potential health risk assessment in Holocene and Pleistocene aquifers in Bangladesh.

This study integrated hydrochemical analysis, isotopic analysis, the integrated water quality index (IWQI), and the health risk assessment model to analyze hydrochemical characteristics, quality, and nitrate health risks in a typical agricultural and industrial (i.e., Holocene and Pleistocene) simultaneously affected by anthropogenic activities, as well as to explore the recharge mechanisms of the groundwater.

Kuramoto model subject to subsystem resetting: How resetting a part of the system may synchronize the whole of it.

We introduce and investigate the effects of a new class of stochastic resetting protocol called subsystem resetting, whereby a subset of the system constituents in a many-body interacting system undergoes bare evolution interspersed with simultaneous resets at random times, while the remaining constituents evolve solely under the bare dynamics. Here, by reset is meant a reinitialization of the dynamics from a given state. We pursue our investigation within the ambit of the well-known Kuramoto model of coupled phase-only oscillators of distributed natural frequencies.

In silico thermal control of spiral wave dynamics in excitable cardiac tissue.

Self-organizing spiral waves of excitation occur in many complex excitable systems. In the heart, for example, they are associated with the occurrence of fatal cardiac arrhythmias such as tachycardia and fibrillation, which can lead to sudden cardiac death. The control of these waves is therefore necessary for the treatment of the disease.

Pancreatic Cancer and Venous Thromboembolism.

Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic cancers and is the most fatal of all cancers. The treatment response from combination chemotherapies is far from satisfactory and surgery remains the mainstay of curative strategies. These challenges warrant identifying effective treatments for combating this deadly cancer.

Melatonin protects against diclofenac induced oxidative stress mediated myocardial toxicity in rats: A mechanistic insight.

Diclofenac, a traditional non-steroidal anti-inflammatory drug, is commonly used for treating chronic pain and inflammation. Recently, a number of articles have highlighted the toxicities associated with diclofenac. The current study explores the molecular mechanism of diclofenac induced cardiac toxicity following oxidative stress.

A Virtual Drug Discovery Screening Illuminates Campesterol as a Potent Estrogen Receptor Alpha Inhibitor in Breast Cancer.

Breast cancer remains a global health challenge, and innovative strategies are required to target estrogen receptor α (ERα), a key player in its development. This study investigates the potential of campesterol, a natural phytosterol, as an ERα inhibitor for breast cancer. Our approach integrates , , and experiments to assess the therapeutic potential of campesterol.

Simulating transient X-ray photoelectron spectra of Fe(CO) and its photodissociation products with multireference algebraic diagrammatic construction theory.

Accurate simulations of transient X-ray photoelectron spectra (XPS) provide unique opportunities to bridge the gap between theory and experiment in understanding the photoactivated dynamics in molecules and materials. However, simulating X-ray photoelectron spectra along a photochemical reaction pathway is challenging as it requires accurate description of electronic structure incorporating core-hole screening, orbital relaxation, electron correlation, and spin-orbit coupling in excited states or at nonequilibrium ground-state geometries. In this work, we employ the recently developed multireference algebraic diagrammatic construction theory (MR-ADC) to investigate the core-ionized states and X-ray photoelectron spectra of Fe(CO) and its photodissociation products (Fe(CO), Fe(CO)) following excitation with 266 nm light.

Consistent Second-Order Treatment of Spin-Orbit Coupling and Dynamic Correlation in Quasidegenerate N-Electron Valence Perturbation Theory.

We present a formulation and implementation of second-order quasidegenerate N-electron valence perturbation theory (QDNEVPT2) that provides a balanced and accurate description of spin-orbit coupling and dynamic correlation effects in multiconfigurational electronic states. In our approach, the energies and wave functions of electronic states are computed by treating electron repulsion and spin-orbit coupling operators as equal perturbations to the nonrelativistic complete active-space wave functions, and their contributions are incorporated fully up to the second order. The spin-orbit effects are described using the Breit-Pauli (BP) or exact two-component Douglas-Kroll-Hess (DKH) Hamiltonians within spin-orbit mean-field approximation.

The Impact on Vergence Parameters After Smartphone Gaming.

Aims: To evaluate the impact of smartphone gaming on the vergence system of the eye.

Settings And Design: A 5-month (from March 2023 to August 2023) comparative and experimental research was conducted.

Materials And Methods: Eighty-two participants with a mean age of 21.

Efficient termination of cardiac arrhythmias using optogenetic resonant feedback pacing.

Malignant cardiac tachyarrhythmias are associated with complex spatiotemporal excitation of the heart. The termination of these life-threatening arrhythmias requires high-energy electrical shocks that have significant side effects, including tissue damage, excruciating pain, and worsening prognosis. This significant medical need has motivated the search for alternative approaches that mitigate the side effects, based on a comprehensive understanding of the nonlinear dynamics of the heart.

Is there a relationship between somatic sensations, impaired vision, and cognitive performance using the factor structure of the convergence insufficiency symptoms survey questionnaire?

Aims: This study aims to evaluate the relationship between somatic sensations, impaired vision, and cognitive performance using the factor structure convergence insufficiency symptoms survey questionnaire in university undergraduate and post-graduate students.

Settings And Design: Centre-based and questionnaire-based.

Subjects And Methods: Subjects were recruited from a university.

Anthropometric Growth Reference for Indian Children and Adolescents.

Objective: We aimed to develop anthropometric growth references for Indian children and adolescents, based on available 'healthy' child data from multiple national surveys.

Methodology: Data on 'healthy' children, defined by comparable WHO's Multicentre Growth Reference Study (MGRS) selection criteria, were extracted from four Indian surveys over the last 2 decades, viz, NFHS-3, 4, and 5 and Comprehensive National Nutrition Survey (CNNS). Reference distributions of height-for-age for children up to 19 years, weight-for-age for children up to 9y, weight-for-height for children less than 5 years and BMI for age for children between 5-19 y were estimated by GAMLSS with Box-Cox Power Exponential (BCPE) family.

Prediction of virus-host interactions and identification of hot spot residues of DENV-2 and SH3 domain interactions.

Dengue virus, particularly serotype 2 (DENV-2), poses a significant global health threat, and understanding the molecular basis of its interactions with host cell proteins is imperative for developing targeted therapeutic strategies. This study elucidated the interactions between proline-enriched motifs and Src homology 3 (SH3) domain. The SH3 domain is pivotal in mediating protein-protein interactions, particularly by recognizing and binding to proline-rich regions in partner proteins.

Development and Evaluation of Ensemble Learning-based Environmental Methane Detection and Intensity Prediction Models.

The environmental impacts of global warming driven by methane (CH) emissions have catalyzed significant research initiatives in developing novel technologies that enable proactive and rapid detection of CH. Several data-driven machine learning (ML) models were tested to determine how well they identified fugitive CH and its related intensity in the affected areas. Various meteorological characteristics, including wind speed, temperature, pressure, relative humidity, water vapor, and heat flux, were included in the simulation.