Numerical study of the effects of minor structures and mean velocity fields in the cerebrospinal fluid flow.

The importance of optimizing intrathecal drug delivery is highlighted by its potential to improve patient health outcomes. Findings from previous computational studies, based on an individual or a small group, may not be applicable to the wider population due to substantial geometric variability. Our study aims to circumvent this problem by evaluating an individual's cycle-averaged Lagrangian velocity field based on the geometry of their spinal subarachnoid space.

Alterations in Circular RNAs circOprm1 and circSerpini in the Striatum are Associated with Changes in Spatial Working Memory Performance after Morphine Dependence and Withdrawal in Rats.

Modulating role of circRNAs and microRNAs in neurobiological changes induced by drug exposure remains unclear. We examined alterations in some circRNAs and microRNAs in the striatum after morphine dependence and withdrawal and their associations with the changes in spatial working memory performance. Male Wistar rats were used in which 10 days morphine exposure induced dependence.

Exploring genotypic variation and gene expression associated to cadmium accumulation in bread wheat.

Cadmium (Cd) contamination poses significant risks to agricultural productivity and human health, particularly through its accumulation in staple crops such as bread wheat (Triticum aestivum L.). This study evaluated Cd accumulation and tolerance among six bread wheat cultivars exposed to six Cd concentrations (0, 2.

Salt stress memory in tall fescue: Interaction of different stress stages, pollination system and genetic diversity.

Introduction: The effects of salinity memory and its interaction with genetic diversity for drought tolerance and pollination system in terms of morphological, physiological, root characteristics and spectral reflectance indices (SRIs) in tall fescue is still unknown.

Methods: Four tall fescue genotypes (two drought-sensitive and two drought-tolerant) were manually controlled to produce four selfed (S1) and four open-pollinated (OP) progeny genotypes (finally eight progeny genotypes). Then all genotypes were assessed for two years in greenhouse under five salinity treatments including control treatment (C), twice salinity stress treatment (primary mild salinity stress in two different stages and secondary at the end stage) (S1t1S2 and S1t2S2), once severe salinity stress treatment (secondary only, S2), and foliar spray of salicylic acid (SA) simultaneously with secondary salinity stress (H2S2).

Effect of mesenchymal stem cells and polyvinyl alcohol-coated selenium nanoparticles on rats with Alzheimer-like phenotypes.

Objectives: Mesenchymal stem cell (MSC) transplantation represents a promising approach for treating Alzheimer's disease (AD). These stem cells, however, have a short lifespan following transplantation into recipient animals. Selenium nanoparticles, due to their size, aid in drug delivery for brain disorders.

Fungal endophytes Fusarium solani SGGF14 and Alternaria tenuissima SGGF21 enhance the glycyrrhizin production by modulating its key biosynthetic genes in licorice (Glycyrrhiza glabra L.).

Aims: To identify promising fungal endophytes that are able to produce glycyrrhizin and enhance it in licorice and the mechanisms involved.

Methods And Results: Fifteen fungal endophytes were isolated from Glycyrrhiza glabra L. rhizomes among which SGGF14 and SGGF21 isolates were found to produce glycyrrhizin by 4.

A critical review of electrochemical and optical Vitamin B6 sensing: evolution of biosensor platforms based on advanced nanosystems.

Vitamin B6 (VB6) is a member of the water-soluble B vitamins which have a vital performance in nervous system operating activities. VB6 is highly demanded to maintain excellent skin and immune systems in the human body. furthermore, VB6 is tremendously substantial in the functions of some enzymes that participate in the metabolism of proteins, amino acids, etc.

Physiological and antioxidant responses of synthetic hexaploid wheat germplasm under drought.

Background: As a result of the world population and climate change impact increases (especially in arid environments), there is a critical need for high-yield, drought-tolerant wheat. Synthetic hexaploid wheat derived lines (SHW-DL), were created artificially by crossing different durum wheat cultivars (AABB) with accessions of Aegilops tauschii (DD), a beneficial source of new genes for common bread wheat (Triticum aestivum L). Here, we studied the response of a panel of 91 SHW-DL for drought tolerance based on physiological, antioxidant enzyme activities, and drought tolerance indices.

Assessing the efficacy of manual reduction and novel traction techniques for distal radius fractures: A randomized controlled trial.

Background And Aim: One of the leading reasons that patients, particularly older persons, are brought to the orthopedic emergency room is a fracture at the end of the radius. In this study, a new traction method for distal radius fractures was compared with manual reduction.

Methods: The census method was used in this clinical trial to study 45 patients (46 hands) who were referred to Hamedan Besat Hospital in 2021.

Non-invasive and probeless rapid in-vitro monitoring and quantification of HUVECs counts based on FFT impedimetery.

Introduction: The endothelial cells derived from the human vein cord (HUVECs) are used as in-vitro models for studying cellular and molecular pathophysiology, drug and hormones transport mechanisms, or pathways. In these studies, the proliferation and quantity of cells are important features that should be monitored and assessed regularly. So rapid, easy, noninvasive, and inexpensive methods are favorable for this purpose.

Adaptive strategies to drought stress in grasses of the poaceae family under climate change: Physiological, genetic and molecular perspectives: A review.

Drought stress is one of the most critical abiotic factors which negatively impacts on growth, productivity, and survival of plants. Grass species have an important role in the sustainable intensification of cropping systems. This review focus on the specific drought tolerance characteristics in grass species and application of prevalent classical and molecular methods for genetic improvement of them to drought stress.

A portable gas sensor based on InO@CuO P-N heterojunction connected via Wi-Fi to a smartphone for real-time carbon monoxide determination.

This research presents a compact portable electronic gas sensor that can be monitored through a smartphone application. The smart sensor utilizes three state-of-the-art sensors. The sensors integrate an ESP8266 microcontroller within the same device.

Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer.

Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NSCLC) subtypes with oncogenic alterations in EGFR, ALK and KRAS. The success of targeted therapy is limited by drug-tolerant persister cells (DTPs) which withstand and adapt to treatment and comprise the residual disease state that is typical during treatment with clinical targeted therapies.

Exploring the potential of SrTiFeO perovskite/Chitosan nanosheets for the development of a label-free electrochemical sensing assay for determination of naproxen in human plasma samples.

Naproxen is a nonsteroidal anti-inflammatory drug used to treat nonrheumatic inflammation, migraine, and gout. Therefore, the determination of naproxen in pharmaceutical and biological samples is of particular importance. In the present work, SrTiFeO perovskite/Chitosan nanosheets were used to modify the surface of a glassy carbon electrode (GCE) for highly sensitive determination of naproxen.

Ultra-thin van der Waals magnetic tunnel junction based on monoatomic boron vacancy of hexagonal boron nitride.

We present a novel strategy to create a van der Waals-based magnetic tunnel junction (MTJ) comprising a three-atom layer of graphene (Gr) sandwiched with hexagonal boron nitride (hBN) layers by introducing a monoatomic boron vacancy in each hBN layer. The magnetic properties and electronic structure of the system were investigated using density functional theory (DFT) and the transmission probability of the MTJ was investigated using the Landauer-Büttiker formalism within the non-equilibrium Green function method. The Stoner gap was created between the spin-majority channel and the spin-minority channel on the local density of states of the hBN monoatomic boron-vacancy (V) near the Fermi energy, creating a possible control of the spin valve by considering two magnetic alignment of hBN(V) layers, anti-parallel configuration (APC) and parallel configuration (PC).

The Inflammation/NF-κB and BDNF/TrkB/CREB Pathways in the Cerebellum Are Implicated in the Changes in Spatial Working Memory After Both Morphine Dependence and Withdrawal in Rat.

We aimed to explore the impact of the cerebellum on the decline in spatial working memory following morphine dependence and withdrawal. Two groups of male Wistar rats received intraperitoneal injections of either saline (1 ml/kg) or morphine (10 mg/kg) twice daily for 10 days, serving as the control and dependent groups. Additionally, a withdrawal group underwent a 30-day withdrawal period after the dependence phase.

Drought stress memory in orchard grass and the role of marker-based parental selection for physiological and antioxidant responses.

Drought stress memory occurring in some plants plays a crucial role in their adaptation to unfavorable conditions. However, in open-pollinated plants, this phenomenon is assumed to be affected by population plasticity resulting from kind and level of diversity and inbreeding depression. Physiological perspectives of drought stress memory in four synthetic poly-crossed populations (groups) of orchard grass (Dactylis glomerata) constructed from parental genotypes with contrasting levels (narrow and wide) of molecular and morphological genetic variation were assessed.

Allelopathic Effect of Aqueous Extracts of Grass Genotypes on L.

The aim of the current research is to evaluate the allelopathic activity of fifty grass genotypes from different species and to identify phenolic compounds in the genotypes that have the highest allelopathic activity and inhibitory effect on L. (Rocket). Aqueous extract was prepared from the leaves of grass genotypes in different concentrations and its effect on germination and growth of L.

Macrophage cell morphology-imprinted substrates can modulate mesenchymal stem cell behaviors and macrophage M1/M2 polarization for wound healing applications.

Mesenchymal stem cells and macrophages (MQ) are two very important cells involved in the normal wound healing process. It is well understood that topological cues and mechanical factors can lead to different responses in stem cells and MQ by influencing their shape, cytoskeleton proliferation, migration, and differentiation, which play an essential role in the success or failure of biomaterial implantation and more importantly wound healing. On the other hand, the polarization of MQ from proinflammatory (M1) to prohealing (M2) phenotypes has a critical role in the acceleration of wound healing.

Multifocal Langerhans' Cell Histiocytosis in an Adult.

Introduction: Multifocal Langerhans' cell histocytosis is a rare condition that can affect multiple organs and manifest in various scenarios. While the condition is more commonly found in children, it can also occur in adults.

Case Report: A 43-year-old female presented with refractory otorrhea and had a rubbery neck mass in the left mid-cervical area, as well as an itchy eczematoid lesion in the left parietal area.

Resveratrol as an antitumor agent for glioblastoma multiforme: Targeting resistance and promoting apoptotic cell deaths.

Glioblastoma multiforme (GBM) is one of the most aggressive brain and spinal cord tumors. Despite the significant development in application of antitumor drugs, no significant increases have been observed in the survival rates of patients with GBM, as GBM cells acquire resistance to conventional anticancer therapeutic agents. Multiple studies have revealed that PI3K/Akt, MAPK, Nanog, STAT 3, and Wnt signaling pathways are involved in GBM progression and invasion.

Ru-Ni nanoparticles electrodeposited on rGO/Ni foam as a binder-free, stable and high-performance anode catalyst for direct hydrazine fuel cell.

Bimetallic Ru-Ni nanoparticles was synthesized on the reduced graphene oxide decorated Ni foam (Ru-Ni/rGO/NF) by electroplating method to be utilized as the anode electrocatalyst for direct hydrazine-hydrogen peroxide fuel cells (DHzHPFCs). The synthesized electrocatalysts were characterized by X-ray diffraction, Field emission scanning electron microscopy, Fourier transform infrared spectroscopy, and Raman spectroscopy. The electrochemical properties of catalysts towards hydrazine oxidation reaction in an alkaline medium were evaluated by cyclic voltammetry, chronoamperometry, and electrochemical impedance spectroscopy.