Efficacy of Adding Sitagliptin to Ongoing Metformin on Metabolic Profile, Triglyceride-Glucose Index, Vitamin D3, and Liver Tests in Patients Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized Clinical Trial.

Background: Dipeptidyl peptidase-4 inhibitors provide potent antidiabetic effects in patients with type 2 diabetes mellitus (T2DM), but their role in the presence of nonalcoholic fatty liver disease (NAFLD) is not well-known.

Objective: The aim of this clinical trial was to evaluate the effects of sitagliptin on the metabolic profile and liver test results in metformin-treated patients with T2DM and NAFLD.

Methods: This was a prospective, 12-week, single-center, comparative randomized clinical trial enrolling 66 adult patients with T2DM and NAFLD (diagnosed by ultrasound).

The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial.

Objective: We hypothesize that synbiotic supplementation could modulate the intestinal microbiota and subsequently, improve the condition of hypothyroid patients.

Methods: Fifty-six adult hypothyroid patients were recruited to this double-blind, placebo-controlled, randomized clinical trial. The intervention was 10 weeks of synbiotic (500 mg of 109 CFU/g probiotics plus fructo-oligosaccharide, n = 28) compared to placebo (lactose, magnesium stearate, talc, and silicon dioxide, n = 28).

Text-based automatic personality prediction using KGrAt-Net: a knowledge graph attention network classifier.

Nowadays, a tremendous amount of human communications occur on Internet-based communication infrastructures, like social networks, email, forums, organizational communication platforms, etc. Indeed, the automatic prediction or assessment of individuals' personalities through their written or exchanged text would be advantageous to ameliorate their relationships. To this end, this paper aims to propose KGrAt-Net, which is a Knowledge Graph Attention Network text classifier.

Toxicity Effects of Engineered Iron Nanoparticles (FeO) on the Growth, Cell Density, and Pigment Content of Chlorella vulgaris.

This study investigated the effects of FeO nanoparticles released from synthesized thiourea catalyst on the biological aspects of Chlorella vulgaris. FeO concentrations (0, 10, 100, 250, 500, 750, and 1000 mg L) were used for the exposure tests. Biological parameters of C.

A model to measure the spread power of rumors.

With technologies that have democratized the production and reproduction of information, a significant portion of daily interacted posts in social media has been infected by rumors. Despite the extensive research on rumor detection and verification, so far, the problem of calculating the spread power of rumors has not been considered. To address this research gap, the present study seeks a model to calculate the Spread Power of Rumor (SPR) as the function of content-based features in two categories: False Rumor (FR) and True Rumor (TR).

Knowledge Graph-Enabled Text-Based Automatic Personality Prediction.

How people think, feel, and behave primarily is a representation of their personality characteristics. By being conscious of the personality characteristics of individuals whom we are dealing with or deciding to deal with, one can competently ameliorate the relationship, regardless of its type. With the rise of Internet-based communication infrastructures (social networks, forums, etc.

Computational investigation on the geometry and electronic structures and absorption spectra of metal-porphyrin-oligo- phenyleneethynylenes-[60] fullerene triads.

In this work, we focus our attention on the influence of 2nd-row transition metals on the structural geometries, electronic structures, and absorption characteristics of porphyrin linked with the C fullerene with oligo-p-phenyleneethynylenes (MP-C-oligo-PPEs) compounds. The DFT/B3PW91-D3 and CAM-B3LYP-D3/6-31G (d) calculations revealed that various metals embedded within the porphyrin moiety give different bridge conformations and different HOMO-LUMO energy levels. We calculate the UV-Vis spectra and absorption parameters using the time-dependent ZINDO/S approach.

Bone mineral density and muscle mass in adults with developmental skeletal discrepancies.

Background: It was aimed to investigate the musculoskeletal status in individuals diagnosed with skeletal discrepancies.

Methods: This case-control study was performed on 35 patients with developmental skeletal discrepancies listed for orthognathic surgery as a case group and 33 patients who were nominated for wisdom tooth removal as a control group. All participants were aged 18-40 years and the research was carried out in the period between May 2018 and May 2019.

The effect of synbiotic supplementation on thyroid hormones, blood pressure, depression and quality of life in hypothyroid patients: A study protocol for a randomized double-blind placebo controlled clinical trial.

Background: The prevalence of hypothyroidism is increasing worldwide. Emerging evidence suggests that modulating the gut microbiota in patients with hypothyroidism through prebiotic and probiotic supplementation may have beneficial health effects. We hypothesize that selective modulation of the intestinal microbiota by synbiotic supplementation could improve metabolic status, mood, and quality of life in hypothyroid patients.

Investigating the demographic characteristics and pathological manifestations of thyroid Cancer during the last two decades (1997-2017) in patients referred to Baqiyatallah hospital, Tehran, Iran.

Background & Objective: Thyroid cancer is among the most common endocrine cancers, and its incidence in our country is in progress over the past decades. This aggravates the necessity to evaluate the changes in thyroid cancer.

Materials & Methods: Through accessing the information of the records of all patients with a diagnosis of thyroid cancer between 1996 and 2017, the present study was conducted at Baqiyatallah Hospital (Tehran, Iran) according to scientific criteria.

Isoniazid-functionalized Fe3O4 Magnetic Nanoparticles as a Green and Efficient Catalyst for the Synthesis of 3, 4-dihydropyrimidin-2(1H)-ones and their Sulfur Derivatives.

Background: A wide variety of dihydropyrimidins (DHPMs) exhibit pharmacological and biological activities. Herein, an efficient one-pot synthesis of some 3, 4-dihydropyrimidin-2(1H)-one derivatives is reported using Fe3O4 @SiO2-Pr-INH.

Objective: Recently, several catalysts have been used to improve the Biginellis-reaction.

Choroidal Thickness and Hemoglobin A1c Levels in Patients with Type 2 Diabetes Mellitus.

Purpose: The aim of this study was to assess the correlation of hemoglobin A1c (HbA1c) levels with choroidal thickness in patients with type 2 diabetes mellitus (DM) using spectral domain optical coherence tomography (SD-OCT).

Methods: In this prospective case series, 180 eyes from 90 patients with type 2 DM were classified into three study groups based on HbA1c values: group 1 included patients with good glycemic control (HbA1c 7%), group 2 included patients with moderate glycemic control (HbA1c between 7% and 8%), and group 3 included patients with poor glycemic control (HbA1c 8%). Additionally, 50 eyes from 25 non-diabetic subjects were enrolled to group 4 as a control group.

Microfunnel-filter-based emulsification microextraction followed by gas chromatography for simple determination of organophosphorus pesticides in environmental water samples.

A simple and fast method named microfunnel-filter-based emulsification microextraction is introduced for an efficient determination of some organophosphorus pesticides including diazinon, malathion, and chlorpyrifos in the environmental samples including the river, sea, and well water. This method is based upon the dispersion of a low-toxicity organic solvent (dihexyl ether), as the extractant, in a high volume of an aqueous sample solution (45 mL). It is implemented without a centrifugation step, and using a syringe filter and a micro-funnel, the phase separation and transfer of the enriched analytes to the gas chromatograph are simply achieved.

A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction.

Lifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is difficult for patients to follow in practice, and remains critical to achieve optimal glucose homeostasis. In this review, we look at what is known about the molecular pathways involved in CR-induced insulin sensitivity and improved insulin resistance.

Simultaneous removal of Pb(II), Cd(II) and bacteria from aqueous solution using amino-functionalized FeO/NaP zeolite nanocomposite.

FeO/NaP nanocomposite was synthesized and modified using 3-aminopropyltrimethoxysilane (3-APTS)-functionalization. FeO/NaP/NH was characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, elemental analysis, energy-dispersive X-ray analysis, vibrating sample magnetometer, Brunauer-Emmett-Teller and thermogravimetric analysis techniques. Batch adsorption studies of Pb(II) and Cd(II) on FeO/NaP/NH were investigated.

Negative correlation of high-density lipoprotein-cholesterol and bone mineral density in postmenopausal Iranian women with vitamin D deficiency.

Objective: The aim of the study was to investigate the association between high-density lipoprotein (HDL) and bone status taking into account serum vitamin D levels in postmenopausal Iranian women.

Methods: During January 2015 and February 2016, a total of 488 postmenopausal Iranian women participated in this cross-sectional study, all of whom were not taking osteoporosis medication and were not suffering from any chronic disorder. Dual X-ray absorptiometry was used to assess bone mineral density (BMD) of the total hip, femoral neck, and lumbar vertebrae (L2-L4).

Solvent-vapor-assisted liquid-liquid microextraction: A novel method for the determination of phthalate esters in aqueous samples using GC-MS.

A novel liquid-liquid microextraction method, namely, solvent-vapor-assisted liquid-liquid microextraction for the determination of dimethyl phthalate, diethyl phthalate, dibutyl phthalate and bis(2-ethylhexyl) phthalate in the aqueous samples using gas chromatography with mass spectrometry was developed. In the proposed method, extracting solvent was heated, and solvent vapor as the extracting phase was injected into the sample solution. As a result of the low temperature of the sample solution and higher density of the extracting phase than the aqueous medium, solvent vapor was condensed and an organic-phase drop formed in the bottom of sample tube.

Direct costs of osteoporosis-related hip fractures: protocol for a cross-sectional analysis of a national database.

Introduction: It is estimated that Iran accounted for about 1% of hip fracture burden of the world in 2007, but these data are based on incomplete evidence. As the country's population is ageing, it is expected that a dramatic rise in hip fracture incidence will result. There is no single national study that accurately estimates the incidence of all hip fractures in the country or identifies the direct costs for affected patients.

Impact of air pollution on vitamin D deficiency and bone health in adolescents.

Unlabelled: The association between air pollution and bone health was evaluated in adolescents in the city of Tehran. This study is essentially ecological. Vitamin D deficiency among adolescents has been reported at higher rates in polluted areas than in non-polluted areas.

Epigenetic Alterations and Exposure to Air Pollutants: Protocol for a Birth Cohort Study to Evaluate the Association Between Adverse Birth Outcomes and Global DNA Methylation.

Background: Prenatal exposure to air pollutants can increase the risk of adverse birth outcomes and susceptibility to a number of complex disorders later in life. Despite this general understanding, the molecular and cellular responses to air pollution exposure during early life are not completely clear.

Objective: The aims of this study are to test the association between air pollution and adverse pregnancy outcomes, and to determine whether the levels of maternal and cord blood and of placental DNA methylation during pregnancy predict adverse birth outcomes in polluted areas.

Vitamin D deficiency, bone turnover markers and causative factors among adolescents: a cross-sectional study.

Background: This cross-sectional population-based study was conducted to elucidate the prevalence of vitamin D deficiency, bone turnover marker's variation and its influencing factors among adolescents of Tehran.

Methods: Totally 444 middle and high school (53.6 % in high school) students (both girls and boys) were recruited.

A quick overview on some aspects of endocrinological and therapeutic effects of Berberis vulgaris L.

Many herbaceous plants contain compounds that have biological effects in addition to their medicinal properties. They have compounds with numerous properties, including hypo lipidemic, hypoglycemic, antioxidant, and hepato protective ones, which have been analyzed at different levels. One of these plants, with the scientific name of Berberis vulgaris, is barberry.

A Suggested Prototype for Assessing Bone Health.

Background: Osteoporosis is becoming a health concern worldwide. Considering the fact that prevention plays an important role in reducing the burden of this silent disease and in view of the limited resources available, many countries have adopted certain programs to fight osteoporosis through shifting their attention towards at-risk individuals. The Iranian Multicenter Osteoporosis Study (IMOS) is one of these programs.

The risk of osteoporotic fractures and its associating risk factors according to the FRAX model in the Iranian patients: a follow-up cohort.

Background: The present study is designed to assess the incidence rate of osteoporotic fracture and its risk factors, particularly those used to predict the 10-year risk of osteoporotic fracture in FRAX based on the data gathered through a follow up cohort initiated in 2000.

Methods: The present retrospective cohort was conducted on men and women from 40 to 90 years of age enrolled in the IROSTEOPs study. A phone survey was conducted during 2013 and beginning of 2014 to assess the fractures (traumatic/osteoporotic) occurring at the time of inclusion until the date of the telephone survey, its type and mechanism, and the patient's age at the time of accident.