Efficacy, safety, and pharmacokinetics of eribulin as monotherapy or in combination with irinotecan for patients with pediatric rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, or Ewing sarcoma.

Background: In this report, we present results from studies of eribulin as monotherapy (Study 223) and in combination with irinotecan (the phase II part of Study 213) for patients with relapsed/refractory pediatric rhabdomyosarcoma (RMS), non-rhabdomyosarcoma soft tissue sarcoma (NRSTS), or Ewing sarcoma (EWS).

Patients And Methods: Studies 223 and 213 were phase II multicenter trials that enrolled pediatric patients with histologically confirmed disease. Treatment comprised 21-day cycles of eribulin mesylate 1.

Are prophylactic antibiotics effective in preventing osteoradionecrosis after high-risk dental extractions?

Study Design: A systematic review and meta-analysis.

Objective: To assess and compare the effectiveness of different adjunctive treatments during tooth extraction in post-radiotherapy head and neck patients for preventing osteoradionecrosis (ORN).

Patients And Methods: Two independent reviewers conducted an electronic search through PubMed, Embase, Cochrane Libraries, Scopus and Web of Science databases using relevant search terms.

Slow drilling technique may enhance peri-operative patient-reported outcomes in dental implant surgery.

Study Design: A randomized, controlled, single-blind clinical trial.

Objective: To assess and compare patient-reported outcome measures (PROMs) between low-speed drilling without irrigation and high-speed drilling with irrigation for implant site preparation.

Patients And Methods: The study adhered to the Declaration of Helsinki principles, obtained approval from the local Ethics Committee, was registered on ClinicalTrials.

How do maternal socioeconomic and behavioral patterns affect oral health in early childhood?

Study Design: A prospective longitudinal observational cohort study.

Cohort Selection: The data analyzed were derived from a comprehensive observational study on BRISA prenatal cohort conducted in São Luís City, Brazil, between 2010 and 2013. A convenience sample included pregnant women recruited from both public and private prenatal health services in the city.

Can narrow-diameter implants enhance patient-reported outcomes for mandibular implant-retained overdentures?

Study Design: A systematic review and meta-analysis.

Objective: To evaluate and compare stability and functionality between narrow and standard implant-retained mandibular overdentures in edentulous patients from multiple perspectives. Assessments included clinical parameters [survival rate (SR) and marginal bone loss (MBL)], along with patient-reported outcome measures (PROMs) including patient satisfaction and oral health-related quality of life (OHRQoL).

Antibiotic prophylaxis may effectively reduce early failures after beginner-conducted dental implant surgery.

Study Design: A randomized, double-blind, placebo-controlled clinical trial.

Objective: To assess the impact of antibiotic prophylaxis on postoperative recovery and implant short-term survival in clinically healthy patients who underwent placement of 2-4 dental implants by inexperienced operators.

Methods: The study adhered to the ethical guidelines of the Helsinki declaration, and followed the CONSORT protocol for randomized controlled trials (RCTs).

Population pharmacokinetic-pharmacodynamic modeling of serum biomarkers as predictors of tumor dynamics following lenvatinib treatment in patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC).

Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor targeting vascular endothelial growth factor (VEGF) receptors 1-3, fibroblast growth factor (FGF) receptors 1-4, platelet-derived growth factor receptor-α (PDGFRα), KIT, and RET that have been implicated in pathogenic angiogenesis, tumor growth, and cancer. The primary objective of this work was to evaluate, by establishing quantitative relationships, whether lenvatinib exposure and longitudinal serum biomarker data (VEGF, Ang-2, Tie-2, and FGF-23) are predictors for change in longitudinal tumor size which was assessed based on data from 558 patients with radioiodine-refractory differentiated thyroid cancer (RR-DTC) receiving either lenvatinib or placebo treatment. Lenvatinib PK was best described by a 3-compartment model with simultaneous first- and zero-order absorption and linear elimination from the central compartment with significant covariates (body weight, albumin <30 g/dL, ALP>ULN, RR-DTC, RCC, HCC subjects, and concomitant CYP3A inhibitors).

Salivary lipid changes in young adult tobacco smokers and e-cigarette users: a hidden risk to oral health?

Study Design: A cross-sectional, age- and gender-matched study was conducted to investigate the effects of different forms of nicotine delivery on salivary lipid profiles among young adult novice smokers compared to non-smokers.

Objective: To assess the effect of smoking traditional cigarettes, e-cigarettes, and heated tobacco products (HTPs) on the levels of specific sphingolipids (sphingosine, sphinganine, and sphingosine-1-phosphate), various ceramides, and lipid peroxidation products [malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE)] in both unstimulated and stimulated saliva samples collected from healthy young adults who had been smoking for 1-3 years and used only 1 of the 3 nicotine delivering methods.

Methods: Selection criteria included healthy young adults under 30 years old, with normal BMI and typical diet composition, and with no oral inflammatory lesions, orthodontic/dental appliances, or recent intake of medications or supplements.

CEMENTED AND SCREW-RETAINED IMPLANT-SUPPORTED RESTORATIONS MAY HAVE A COMPARABLE RISK FOR PERI-IMPLANT MUCOSITIS AND PERI-IMPLANTITIS.

Article Title And Bibliographic Information: Reis INRD, Fukuoka GL, Nagay BE, Pannuti CM, Spin-Neto R, Silva EVFD. Incidence of peri-implant disease associated with cement- and screw-retained implant-supported prostheses: A systematic review and meta-analysis. J Prosthet Dent.

Impact of Concentration Polarization Phenomena on Gas Separation Processes with High-Performance Zeolite Membranes: Experiments vs. Simulations.

Polarization phenomena play a key role in membrane separation processes but remain largely unexplored for gas separations, where the mass transfer resistance is most often limited to the membrane. This assumption, which is commonly used today for the simulation of membrane gas separations, has to be reconsidered when high-performance materials, showing a very high permeance and/or selectivity, are used. In this study, a series of steady-state separation performances experimentally obtained on CO/CH mixtures with a zeolite membrane are compared to the predictions of a dedicated 1D approach, recently derived and validated through CFD simulations.

How far does feedback on oral malodor assessment influence the decision to quit smoking?

Design: A retrospective, uncontrolled, questionnaire-based, pre-post study involving adult male smoker volunteers who were invited to attend a one-day smoking cessation event at their workplace.

Objective: To assess the effect of feedback on motivation for smoking cessation using oral-malodor measurements.

Methods: At baseline, the participants attended a brief video presentation regarding various oral health-specific effects of smoking, joined a group introduction to smoking-cessation aids, and were given questionnaires that inquired information about smoking status including type, daily consumption, and duration.

Preliminary evidence of impaired oral wound healing in e-cigarette users: a call for perioperative vaping cessation.

Design: A prospective, parallel-arm, age- and gender-matched clinical study.

Objective: To assess and compare palatal wound healing of orally and systemically healthy e-cigarette users with a matched group of non-vapers.

Methods: Included were healthy adult volunteers (18-50 years), either e-cigarette users or never smokers, who agreed to use a study-specific e-cigarette device and e-liquids, and were willing to provide consent from.

Dose- and time-dependent association of smoking and its cessation with risk of peri-implant diseases.

Design: A retrospective cohort study involved patients who received at least one implant-supported restoration at a university dental clinic between 2001 and 2013. Patients were randomly selected from an electronic database, and their recruitment via telephone contact spanned from February 2021 until July 2021.

Main Objective: To investigate the association of smoking and its cessation with the risk of peri-implant mucositis and peri-implantitis in a cohort of implant-treated patients.

FOR IMMEDIATE IMPLANT PLACEMENT, SOCKET SHIELD TECHNIQUE MAY SIGNIFICANTLY REDUCE MARGINAL BONE LOSS AS COMPARED TO CONVENTIONAL PROTOCOL.

Article Title And Bibliographic Information: Clinical outcomes of retention of the buccal root section combined with immediate implant placement: A systematic review of longitudinal studies. Kotsakis GA, Nguyen TT, Siormpas K, Pikos MA, Pohl S, Tarnow D, Mitsias M, Root Membrane Group. Clin Implant Dent Relat Res.

Dose-response association of smoking with delayed healing of apical periodontitis after endodontic treatment.

Design: A prospective cohort study aimed to assess the inhibitory effect of cigarette smoking on the rate of periapical bone healing after root canal treatment (RCT). Examination included both clinical and radiographic parameters to define healing status at baseline, 6 months, and 1 year after RCT.

Objectives: To examine and compare the healing rate of apical periodontitis (AP) after RCT between smokers and nonsmokers, and to evaluate how the intensity and duration of smoking affect AP healing up to 1-year follow-up.

Mind games in dentistry: confounded evidence suggests a substantial nocebo response in dental impaction pain model.

Design: A systematic review and metaanalysis of randomized clinical trials (RCTs).

Data Sources: Electronic search was conducted in PubMed, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL), on 22 May 2021.

Selection Criteria: Eligibility criteria included parallel-group placebo-controlled RCTs assessing analgesics after third molar (M3) surgery in healthy patients, reporting the number of patients with at least one drug-related adverse event (AE), and being published in English.

Does flapless immediate implant placement lead to significant preservation of buccal bone compared to flap surgical protocol?

Design: A systematic review and meta-analysis of randomized clinical trials.

Data Sources: The electronic search included Pubmed, Web of Science, Embase, and Cochrane databases up to June 2022. Cross-referencing, searching for gray literature at ( www.

Further evidence confirms the association between smoking and dry socket: a motivational opportunity for tobacco cessation.

Design: A systematic review and meta-analysis of observational studies.

Data Sources: Electronic search included PubMed, Scopus, and Web of Science databases up to March 2022 using appropriate keywords.

Selection Criteria: The review included all observational studies (case-control, cohort and cross-sectional studies) published in English after 2000, comparing the prevalence of dry socket between smokers and non-smokers after simple or surgical tooth extraction.

Exploring biomedical and traditional care pathways for people with psychosis in Karachi, Pakistan.

Background: Psychosis is known to have an adverse impact on an individual's quality of life, social and occupational functioning. A lack of treatment options for psychotic disorders such as schizophrenia contributes to adverse outcomes for individuals. A significant proportion of people with psychosis consult both formal and traditional routes of care.

Young Patients' Satisfaction Following the Correction of Adolescent Idiopathic Scoliosis in Saudi Arabia: A Cross-Sectional Study.

Introduction: Posterior spinal instrumented fusion remains the mainstay treatment for adolescent idiopathic scoliosis (AIS) with acceptable post-operative patient satisfaction. However, in Saudi Arabia, patient satisfaction after surgical management for AIS has not been thoroughly studied. The purpose of this study was to determine patient satisfaction and quality of life using the Scoliosis Research Society-22r (SRS-22r, the most recent version) questionnaire after surgical correction of AIS in Saudi Arabia.

Intravenous Perampanel as an Interchangeable Alternative to Oral Perampanel: A Randomized, Crossover, Phase I Pharmacokinetic and Safety Study.

Intravenous (IV) drug administration enables treatment of epilepsy when oral administration is temporarily not feasible. Perampanel is a once-daily antiseizure medication currently available as oral formulations. Study 050 (NCT03376997) was an open-label, randomized, single-dose, crossover study to evaluate the interchangeability of oral and IV perampanel in healthy subjects (N = 48).

Articaine improves anesthetic achievement for exodontia performed by undergraduate dental students: A clinical comparative study.

Purpose/objectives: To assess the clinical performance of undergraduate dental students in delivering inferior alveolar nerve block (IANB) with either articaine or lidocaine, and to compare the success rate of their IANBs between articaine and lidocaine for the extraction of mandibular molar teeth.

Methods: In this clinical trial, patients were randomly distributed into 2 study groups: articaine and lidocaine groups. In each group, dental students performed IANB followed by forceps extraction of 1 mandibular molar under close supervision.

Population Pharmacokinetics and Exposure-Response Analyses for the Most Frequent Adverse Events Following Treatment With Lemborexant, an Orexin Receptor Antagonist, in Subjects With Insomnia Disorder.

Lemborexant is a novel orexin receptor antagonist approved in the United States and Japan for the treatment of insomnia. This article describes the population pharmacokinetics (PK) of lemborexant and the relationship of its daily steady-state exposure (C ) to the probability of most frequent treatment-emergent adverse events (TEAEs). The 12 230-observation, 1892-subject PK data set included data from 12 clinical studies with predominantly female subjects (66%) ranging in age from 18 to 88 years and from 37 to 168 kg in body weight.