Publications by authors named "Majid Nikoubin-Boroujeni"
Genomic determinants in pathogenicity of SARS-CoV-2 versa common cold coronaviruses.
Nucleosides Nucleotides Nucleic Acids
November 2024
Article Synopsis
- Researchers studied the full genomes of both fatal and mild coronavirus strains to understand how they evolved into more virulent forms by analyzing short oligonucleotide features.
- They calculated the frequency of various short nucleotide sequences (from dinucleotides to hexanucleotides) using the Markov method and computed odds ratios to create a set of raw data for analysis.
- By applying ten different weighting algorithms, they identified specific oligonucleotide motifs, like CC and CACCAC, that could help distinguish between virulent and mild strains, potentially pointing to RNA elements linked to viral virulence for future treatment targets.*