Palladium-immobilized triazine dendrimer on magnetic nanoparticles: as reusable microreactor for solvent-dependent synthesis strategy of 2,3-diphenylindoles and pentaphenylpyrrole derivatives.

In this work, we demonstrate that palladium-immobilized triazine dendrimer on magnetic nanoparticles in proper solvents, provides an impressive, atom-economical and compelling approach for the selective synthesis of 2,3-diphenylindole or pentaphenylpyrrole derivatives via annulation of diphenylacetylene with diverse anilines. Both the annulation methods were taken place under copper- and phosphine-free conditions with high yields at air atmosphere. Likewise, bis-indoles were obtained with excellent yields under optimized reaction conditions.

Genetically engineered phages and engineered phage-derived enzymes to destroy biofilms of antibiotics resistance bacteria.

"An impregnable stronghold where one or more warrior clans can evade enemy attacks" may serve as a description of bacterial biofilm on a smaller level than human conflicts. Consider this hypothetical conflict: who would emerge victorious? The occupants of secure trenches or those carrying out relentless assault? Either faction has the potential for triumph; the defenders will prevail if they can fortify the trench with unwavering resolve, while the assailants will succeed if they can devise innovative means to breach the trench. Hence, bacterial biofilms pose a significant challenge and are formidable adversaries for medical professionals, often leading to the failure of antibiotic treatments in numerous hospital infections.

Unveiling the key role of metal coordination mode and ligand's side groups on the performance of deep-red light-emitting electrochemical cell.

Three novel deep-red to near-infrared (DR to NIR) emitters based on mononuclear and dinuclear ruthenium(II) complexes with bulky structures were presented herein. For the first time, the unusual effects of metal coordination mode on the electroluminescence properties of a binuclear emitter were investigated. Unexpectedly, the mononuclear complexes showed superior performance in deep-red light-emitting electrochemical cells (DR-LEC) compared to the dinuclear complex.

A pH-dependent and charge selective covalent organic framework for removal of dyes from aqueous solutions.

A novel imine-linked COF is synthesized by the condensation of 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) and 2-hydroxy-5-methoxyisophthalaldehyde (HMIPA) under solvothermal conditions. This COF adsorbs preferentially the neutral dye Neutral Red (NR) over the positively charged dye Methylene Blue (MB) at pH 7, and the negatively charged Methyl Orange (MO) over the positively charged Methylene Blue (MB) at pH 3. The maximum adsorption capacities (q) obtained within very short times (11-60 min) under optimized conditions were 108, 185 and 429 mg.

Surface Engineering of Superparamagnetic Graphene Oxide Nanosheet as a Chemically Tunable Platform for Facial Biofuel Production by Lipase.

In this research, we utilized an efficient approach to synthesize superparamagnetic graphene oxide (SPGO) rapidly in a one-pot method using microwave irradiation of graphene oxide (GO), urea, and Fe(III) ion. Tannic acid (TA) was introduced to the surface of SPGO through a straightforward and eco-friendly process. Methods were devised to furnish GO nanosheets and modify their surfaces with TA in an environmentally friendly manner.

Upregulation of , , , , , and genes contributing to resistance to colistin in superbug isolates from human clinical samples in Tehran, Iran.

Background: Antibiotic resistance in isolates, particularly resistance to colistin, has become a growing concern. This study seeks to investigate the upregulation of specific genes (, , , , , and ) that contribute to colistin resistance in isolates collected from human clinical samples in Tehran, Iran.

Methods: Thirty eight isolates were obtained and subjected to antibiotic susceptibility testing, as well as evaluation for phenotypic AmpC and ESBL production according to CLSI guidelines.

Virulence Genes and Biofilm Formation Among Legionella pneumophila Isolates Collected from Hospital Water Sources.

Legionella pneumophila can be transmitted to people, especially immunocompromised patients, via hospital water pipe systems and cause severe pneumonia. The aim of our study was to investigate the presence of major virulence factor genes, ability of biofilms formation, and correlation between presence of Legionella isolates and temperature, pH, and residual chlorine of water. Hundred water samples were collected from nine hospitals in Tehran, Iran.

Stability enhancement of perovskite solar cells using multifunctional inorganic materials with UV protective, self cleaning, and high wear resistance properties.

Organometal halide perovskite solar cells have reached a high power conversion efficiency of up to 25.8% but suffered from poor long-term stability against environmental factors such as ultraviolet irradiation and humidity of the environment. Herein, two different multifunctional transparent coatings containing AZO and ZnO porous UV light absorbers were employed on the front of the PSCs.

Phage therapy as a glimmer of hope in the fight against the recurrence or emergence of surgical site bacterial infections.

Purpose: Over the last decade, surgery rates have risen alarmingly, and surgical-site infections are expanding these concerns. In spite of advances in infection control practices, surgical infections continue to be a significant cause of death, prolonged hospitalization, and morbidity. As well as the presence of bacterial infections and their antibiotic resistance, biofilm formation is one of the challenges in the treatment of surgical wounds.

Efficient synthesis of novel thiadiazolo[2,3-b]quinazolin-6-ones catalyzed by diphenhydramine hydrochloride-CoCl⋅6HO deep eutectic solvent.

In this research, a new Lewis acid-based deep eutectic solvent (LA-DES) was synthesized using diphenhydramine hydrochloride and CoCl·6HO, (2[HDPH]:CoCl), and identified by FT-IR and HNMR techniques. The physicochemical properties of this LA-DES, such as thermal behavior, thermal stability, and solubility in common solvents were also investigated. The catalytic ability of 2[HDPH]:CoCl was ascertained in the efficient synthesis of a novel array of thiadiazolo[2,3-b]quinazolin-6-one scaffolds via a one-pot three-component reaction of dimedone/1,3-cyclohexanedione, aldehydes, and 5-aryl-1,3,4-thiadiazol-2-amines/3-(5-amino-1,3,4-thiadiazol-2-yl)-2H-chromen-2-one under solvent-free conditions.

The enzymatic synthesis of lactose caprate using lipase immobilized into ZIF-8 and investigation of its anticancer applications against K562 leukemia and HeLa cancer cells.

In this study, a lactose fatty acid ester was enzymatically synthesised using immobilized lipase (CRL). Its anticancer property against K562 leukemia and HeLa cancer cells was carefully investigated. In the first step, a strategy was applied to encapsulate CRL into a microporous zeolite imidazolate framework called ZIF-8.

Engineered phage enzymes against drug-resistant pathogens: a review on advances and applications.

In recent decades, the expansion of multi and extensively drug-resistant (MDR and XDR) bacteria has reached an alarming rate, causing serious health concerns. Infections caused by drug-resistant bacteria have been associated with morbidity and mortality, making tackling bacterial resistance an urgent and unmet challenge that needs to be addressed properly. Endolysins are phage-encoded enzymes that can specifically degrade the bacterial cell wall and lead to bacterial death.

Triazine diphosphonium tetrachloroferrate ionic liquid immobilized on functionalized halloysite nanotubes as an efficient and reusable catalyst for the synthesis of mono-, bis- and tris-benzothiazoles.

Aminopropyl-1,3,5-triazine-2,4-diphosphonium tetrachloroferrate immobilized on halloysite nanotubes [(APTDP)(FeCl)@HNT] was prepared and fully characterized using different techniques such as FT-IR, thermogravimetric analysis (TGA), SEM/EDX, elemental mapping, TEM, ICP-OES, and elemental analysis (EA). This nanocatalyst was found to be highly effective for synthesis of various benzothiazole derivatives in excellent yields under solvent-free conditions. Furthermore, bis- and tris-benzothiazoles were smoothly synthesized from dinitrile and trinitrile in the presence of this catalytic system.

The therapeutic effect of engineered phage, derived protein and enzymes against superbug bacteria.

Defending against antibiotic-resistant infections is similar to fighting a war with limited ammunition. As the new century unfolded, antibiotic resistance became a significant concern. In spite of the fact that phage treatment has been used as an effective means of fighting infections for more than a century, researchers have had to overcome many challenges of superbug bacteria by manipulating phages and producing engineered enzymes.

Perturbations in Microbiota Composition as a Novel Mediator in Neuropsychiatric, Neurological and Mental Disorders: Preventive and Therapeutic Complementary Therapies to Balance the Change.

Although microbiology and neurology are separate disciplines, they are linked to some infectious and neurological diseases. Today, microbiome is considered as one of the biomarkers of health by many researchers. This has led to the association of microbiome changes with many neurological diseases.

Green synthesize of nano-MOF-ethylcellulose composite fibers for efficient adsorption of Congo red from water.

Two novel MOF- ethyl cellulose (EC)- based nanocomposites have been designed and synthesized in water by electrospinning and applied for adsorption of congo red (CR) in water. Nano- Zeolitic Imidazolate Framework-67 (ZIF-67), and Materials of Institute Lavoisier (MIL-88A) were synthesized in aqueous solutions by a green method. To enhance the dye adsorption capacity and stability of MOFs, they have been incorporated into EC nanofiber to prepare composite adsorbents.

Carbonic Anhydrase-Embedded ZIF-8 Electrospun PVA Fibers as an Excellent Biocatalyst Candidate.

There is a growing concern that the increasing concentration of CO in the atmosphere contributes to a potential negative impact on global climate change. To deal with this problem, developing a set of innovative, practical technologies is essential. In the present study, maximizing the CO utilization and precipitation as CaCO was evaluated.

Diphenhydramine Hydrochloride-CuCl as a New Catalyst for the Synthesis of Tetrahydrocinnolin-5(1)-ones.

The current study deals with the synthesis and characterization of a novel catalyst made from diphenhydramine hydrochloride and CuCl ([HDPH]Cl-CuCl). The prepared catalyst was thoroughly characterized using various techniques, such as H NMR, Fourier transform-infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis and derivative thermogravimetry. More importantly, the observed hydrogen bond between the components was proven experimentally.

Self-healing perovskite solar cells based on copolymer-templated TiO electron transport layer.

Inorganic hole-transport materials (HTMs) such as copper indium disulfide (CIS) have been applied in perovskite solar cells (PSCs) to improve the poor stability of the conventional Spiro-based PSCs. However, CIS-PSCs' main drawback is their lower efficiency than Spiro-PSCs. In this work, copolymer-templated TiO (CT-TiO) structures have been used as an electron transfer layer (ETL) to improve the photocurrent density and efficiency of CIS-PSCs.

Phenanthroimidazole as molecularly engineered switch for efficient and highly long-lived light-emitting electrochemical cell.

Light-emitting electrochemical cells (LECs) based on Ir(III) complexes owing to the superior advantages exhibit high potential for display and lighting applications. Herein, a series of Ir(III) complexes based on phenanthroimidazole (PI) as an ancillary ligand were synthesized to achieve efficient and highly stable yellow-to-orange LEC devices with fast response. These complexes exhibit appropriate electrochemical stability and significant suppression of concentration quenching in the thin films compared to the archetype complex.

3-(Propylthio)propane-1-sulfonic acid immobilized on functionalized magnetic nanoparticles as an efficient catalyst for one-pot synthesis of dihydrotetrazolo[1,5-]pyrimidine and tetrahydrotetrazolo[5,1-]quinazolinone derivatives.

An efficient and reusable catalyst, which is 3-(propylthio)propane-1-sulfonic acid immobillized on functionalized magnetic nanoparticles [PTPSA@SiO-FeO], has been synthesized. For the first time, it is highlighted under solvent-free conditions for the catalytic activity in multicomponent synthesis of dihydrotetrazolo[1,5-]pyrimidines, dihydrotetrazolo[1,5-]pyrimidine-6-carboxylates and tetrahydrotetrazolo[5,1-]quinazolinones. The structure of the catalyst was well confirmed by characterization techniques, such as FT-IR, TGA, SEM-EDX, elemental mapping, TEM, VSM and elemental analysis.

The Effect of Bacterial Composition Shifts in the Oral Microbiota on Alzheimer's Disease.

Alzheimer's disease (AD), a neurological disorder, despite significant advances in medical science, has not yet been definitively cured, and the exact causes of the disease remain unclear. Due to the importance of AD in the clinic, large expenses are spent annually to deal with this neurological disorder, and neurologists warn of an increase in this disease in elderly in the near future. It has been believed that microbiota dysbiosis leads to Alzheimer's as a multi-step disease.