Dextrin-assisted gel electromembrane extraction of chiral drugs: Improving the extraction efficiency and investigation of enantioselectivity of extraction.

The present study investigates the use of dextrins (maltodextrin, β-cyclodextrin, and hydroxypropyl-β-cyclodextrin) to improve the efficiency of the agarose-based gel electromembrane extraction technique for extracting chiral basic drugs (citalopram, hydroxyzine, and cetirizine). Additionally, it examines the enantioselectivity of the extraction process for these drugs. To achieve these, dextrins were incorporated into either the sample solution, the membrane, or the acceptor solution, and then the extraction procedure was performed.

In-tube gel electromembrane extraction: A green strategy for the extraction of narcotic drugs from biological samples.

The development of green and miniature extraction methods is always a major and controversial challenge in the field of sample preparation. In this work, in-tube gel electromembrane extraction (IT-G-EME) was developed as a miniaturized extraction device for the extraction of six narcotic drugs (codeine, oxycodone, hydrocodone, tramadol, thebaine, and noscapine) from biological samples. A transparent capillary tube (∼6 cm) was used as a microextraction unit.

Analysis of methamphetamine, methadone, tramadol, and buprenorphine in biological samples by ion mobility spectrometry after electromembrane extraction in tandem with slug flow microextraction.

A novel tandem extraction method based on electromembrane extraction (EME) and slug flow microextraction (SFME) was developed for the extraction of some narcotics (methamphetamine, methadone, tramadol, and buprenorphine) from biological samples. The analytes were quantified by corona discharge-ion mobility spectrometry (CD-IMS). In this method, initially, analytes were extracted using an EME procedure (step-1).

Preparation of electrospun polyacrylonitrile/ϒ-cyclodextrin metal-organic framework nanofibers for extraction of multi-classes herbicides from cereal samples before HPLC-UV analysis.

This study employed thin-film solid-phase microextraction procedure as a simple, sensitive, green, and solvent-free method for the co-extraction of multi-classes herbicides from cereal samples before HPLC-UV analysis. To provide an efficient sorbent, electrospun nanofibers of the crosslinked polyacrilonitril/ϒ-cyclodextrin-metal-organic framework (PAN/ϒ-CD-MOF) were successfully fabricated and assessed as a new thin-film adsorbent. Under the optimal conditions (desorption solvent: acetonitrile, desorption time: 5 min, sample solution pH: 7.

Two-phase agarose gel-electromembrane extraction: Effect of organic solvent as an acceptor phase in electroendosmosis flow phenomenon.

In this study, a new mode of gel electromembrane extraction (G-EME) namely as "Two-phase G-EME", is suggested for the sensitive quantification of five basic drugs (desipramine, clomipramine, trimipramine, citalopram and clozapine) in biological samples. Compared to classical G-EME which is based on aqueous-gel-aqueous layout, herein, the aqueous acceptor phase (AP) was replaced with organic solvent. Briefly, negative electrode was immersed into the organic AP (with low conductivity) and positive electrode into the aqueous donor phase (DP).