Publications by authors named "Majid Karamat"
Article Synopsis
- The study examines the microevolution of Giardia lamblia, tracking gene migration and transmission between adjacent counties in northwest Iran, specifically focusing on samples from Tabriz and Ardabil cities.
- A total of 33 fecal samples were analyzed for identifying G. lamblia assemblages using PCR-RFLP methods targeting the glutamate dehydrogenase locus, resulting in 81.9% identified as assemblage A (genotype AII) and 9% each for assemblage B (genotype BIII) and a mixed genotype.
- Despite varied gastrointestinal symptoms, genetic analysis revealed low diversity in sub-assemblage AII and indicated ongoing gene flow between populations, suggesting a need for more extensive studies on the genetic
Microevolutionary data of Giardia duodenalis sub-assemblages is a prerequisite for determining the invasion zoonotic patterns of the parasite. To infer transmission patterns that could not be differentiated by the phenotypic features, a population genetic investigation is crucial for the elucidation of the genetic structure of G. duodenalis among the continents.
View Article and Find Full Text PDFObjective: To identify the frequencies (F) of ferredoxin and nitroreductase mutations on Iranian clinical isolates of Giardia lamblia in order to predict whether the nitazoxanide can be prescribed as suitable drug for symptomatic to metronidazole-resistant giardiasis.
Methods: Forty Giardia lamblia isolates as of 38 symptomatic and two metronidazole-resistant patients were collected from Iran. DNAs were extracted and amplified by targeting ferredoxin and GlNR genes.