Effect of cell imprinting on viability and drug susceptibility of breast cancer cells to doxorubicin.

This study demonstrates the effect of substrate's geometrical cues on viability and the efficacy of an anti-cancer drug, doxorubicin (DOX), on breast cancer cells. It is hypothesized that the surface topographical properties can mediate the cellular drug intake. Pseudo-three dimensional (3D) platforms were fabricated using imprinting technique from polydimethylsiloxane (PDMS) and gelatin methacryloyl (GelMA) hydrogel to recapitulate topography of cells' membranes.

A Mathematical Model for Vibration Behavior Analysis of DNA and Using a Resonant Frequency of DNA for Genome Engineering.

The DNA molecule is the most evolved and most complex molecule created by nature. The primary role of DNA in medicine is long-term storage of genetic information. Genetic modifying is one of the most critical challenges that scientists face.

Influence of various setting angles on vibration behavior of rotating graphene sheet: continuum modeling and molecular dynamics simulation.

The Eringen's nonlocal elasticity theory is employed to examine the free vibration of a rotating cantilever single-layer graphene sheet (SLGS) under low and high temperature conditions. The governing equations of motion and the related boundary conditions are obtained through Hamilton's principle based on the first-order shear deformation theory (FSDT) of nanoplates. The generalized differential quadrature method (GDQM) is utilized to solve the nondimensional equations of motion.