-repeat polymorphism in the tissue plasminogen activator () gene, seminal t-PA concentration, and male fertility impairment: A case-control study.

Background: Tissue plasminogen activator (t-PA) is a protein involved in the fibrinolytic system that catalyzes the conversion of plasminogen into the active plasmin. The activity of t-PA is controlled by plasminogen activator inhibitor-1. t-PA has crucial functions during spermatogenesis.