Ischemic Stroke Revealing Libman-Sacks Endocarditis as the Initial Manifestation of Lupus Erythematosus With Secondary Antiphospholipid Syndrome: A Case Report.

Libman-Sacks endocarditis (LSE), also known as nonbacterial thrombotic endocarditis (NBTE), is a rare condition characterized by noninfectious lesions on the heart valves with the deposition of thrombi. NBTE is most commonly linked to advanced malignancy, systemic lupus erythematosus, and antiphospholipid syndrome (APS). In many cases, NBTE is only diagnosed postmortem during autopsies, with embolization being the most frequent clinical manifestation.

Non-rheumatic Streptococcal Acute Myocarditis: The First Documented Sibling Case.

Myocarditis is an inflammatory disease of the cardiac muscle that manifests as chest pain, dyspnea, and other signs of heart failure. ST segment changes with elevated cardiac biomarkers mimic acute coronary syndromes. It is most commonly caused by viruses like the Epstein-Barr virus (EBV) and Coxsackie B virus, but it can also be due to cardiotoxic drugs like cyclophosphamide and cocaine or caused by a systemic infiltrative process like sarcoidosis or collagen vascular diseases.

Renal Involvement in Thrombotic Thrombocytopenic Purpura: Is It Time to Challenge the Old Paradigm?

Thrombotic thrombocytopenic purpura (TTP) is clinical-pathological entity characterized by microangiopathic hemolytic anemia associated with end-organ dysfunction. Traditionally, TTP was characterized by the classic pentad of fever, thrombocytopenia, hemolytic anemia, renal impairment, and neurological manifestations. However, this classic pentad is only observed in 40% of cases.