Therapeutic Drug Monitoring of Vancomycin in Jordanian Patients. Development of Physiologically-Based Pharmacokinetic (PBPK) Model and Validation of Class II Drugs of Salivary Excretion Classification System (SECS).

Vancomycin is a commonly used antibiotic for multi-drug resistant gram-positive infections treatment, especially methicillin-resistant Staphylococcus aureus (MRSA). Despite that, it has wide individual pharmacokinetic variability and nephrotoxic effect. Vancomycin trough concentrations for 57 Jordanian patients were measured in plasma and saliva through immunoassay and liquid chromatography-mass spectrometry (LC-MS/MS), respectively.

Diagnosis of Breast Cancer Pathology on the Wisconsin Dataset with the Help of Data Mining Classification and Clustering Techniques.

Breast cancer must be addressed by a multidisciplinary team aiming at the patient's comprehensive treatment. Recent advances in science make it possible to evaluate tumor staging and point out the specific treatment. However, these advances must be combined with the availability of resources and the easy operability of the technique.