Effect of short‑term testosterone replacement therapy on heart rate variability in men with hypoandrogen‑metabolic syndrome.

Introduction:  Testosterone deficiency syndrome (TDS) is characterized by clinical signs of testosterone deficiency in men with reduced testosterone levels. It leads to endothelial dysfunction, which, apart from erectile dysfunction, accelerates atherosclerosis progression.

Objectives:  The aim of the study was to evaluate the effect of testosterone supplementation in men with metabolic syndrome (MS) and TDS on autonomic balance assessed by heart rate variability (HRV) in 24‑hour Holter monitoring.

[The relationship between testosterone deficiency and metabolic syndrome in obese men].

Unlabelled: In aging males testosterone decreases approximately 0,8-1% annually. This physiological process can be intensified in obesity and metabolic syndrome (MS). Progressive testosterone deficiency can exacerbate existing metabolic disorders, leading to a vicious circle.