Publications by authors named "Maja Patricia Smerdel"
Introduction: Sertoli-Leydig cell tumors are rare tumors of the ovary. Moderate and poorly differentiated tumors can metastasize and have a poor outcome. A pathogenic variant in is associated with an increased risk of developing these tumors along with other clinical phenotypes.
View Article and Find Full Text PDFPurpose: Treatment of multi-resistant epithelial ovarian cancer represents a clinical challenge with limited choices. Anti-angiogenic therapy has shown great potential in combination with frontline-therapy. Studies investigating heavily pre-treated patients are few.
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- - Cowden syndrome, caused by mutations in the PTEN gene, significantly raises the risk of several cancers including breast, thyroid, and colorectal cancers, making regular surveillance essential for affected individuals.
- - The study involved a thorough review of literature from 1996 to 2017, identifying 2078 papers but narrowing to 11 that provided relevant and high-quality information to create management guidelines.
- - The findings highlighted the specific cancer risks associated with Cowden syndrome and led to the proposal of updated management guidelines tailored for patients in Denmark.
Introduction: Vascular endothelial growth factors (VEGFs) play a central role in angiogenesis and consequently, in various steps of ovarian carcinogenesis. Gene polymorphisms within the VEGF system have revealed a correlation with prognosis in some malignancies. The aim of the present study was to examine the possible importance of 2 VEGF polymorphisms and VEGF-A expression in ovarian cancer.
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