Publications by authors named "Maja Kuzman"
Article Synopsis
- Circulating tumor DNA (ctDNA) can help detect residual cancer after treatment, but its low levels make detection tough; tumor-informed whole-genome sequencing (WGS) offers a solution using numerous mutations for better ctDNA identification.
- * In a study with 144 stage III colorectal cancer patients and 1283 plasma samples, WGS created a unique mutational fingerprint that improved ctDNA detection and demonstrated excellent reproducibility across labs.
- * Results showed that ctDNA detection post-surgery and post-chemotherapy strongly predicted cancer recurrence, often identifying it months before standard imaging; the study highlights the potential for WGS to track cancer evolution and treatment effects.*
Background And Objective: Circulating tumor DNA (ctDNA) can be used for sensitive detection of minimal residual disease (MRD). However, the probability of detecting ctDNA in settings of low tumor burden is limited by the number of mutations analyzed and the plasma volume available. We used a whole-genome sequencing (WGS) approach for ctDNA detection in patients with urothelial carcinoma.
View Article and Find Full Text PDFHIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4 T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for HIV-1 integration have so far remained unclear. Here we show that recurrently targeted genes are proximal to super-enhancer genomic elements and that they cluster in specific spatial compartments of the T cell nucleus.
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- * A study found that LTRs from the ERVL retrotransposon class significantly influence gene expression during the oocyte-to-embryo transition in various species, including mice and humans, by activating transcription and altering gene sequences.
- * The research highlights that ERVL LTRs can recycle genetic material, such as pseudogenes into functional RNAs, and even contribute to the evolution of new genes, demonstrating their vast potential for reshaping genome expression and evolution.