Purpose: We aimed to establish the spectrum of BRCA1/2 mutations among the breast cancer (BC) patients from the Republic of Macedonia.
Methods: We used targeted next-generation sequencing (NGS), Sanger DNA sequencing, and multiplex ligation probe amplification analysis (MLPA) to search for point mutations and deletions/duplications involving BRCA1 and BRCA2-coding regions.
Results: We have analyzed a total of 313 BC patients, enriched for family history of cancer, early age of onset and bilateral and/or triple negative (TN) BC.
Aim: The purpose of this study is to describe our experience with needle localization technique in diagnosing small breast cancers.
Material And Methods: This retrospective study included a hundred and twenty patients' with impalpable breast lesions and they underwent wire localization. All patients had mammography, ultrasound exam and pathohystological results.