Stable Frequencies of HLA-C03:04/Peptide-Binding KIR2DL2/3 Natural Killer Cells Following Vaccination.

Inhibitory KIRs play a central role in regulating NK cell activity. KIR2DL2/3 bind to HLA-C molecules, but the modulation of these interactions by viral infections and presentation of viral epitopes is not well-understood. We investigated whether the frequencies of KIR2DL2/3 NK cells recognizing HLA-C03:04/viral peptide complexes were impacted by YFV vaccination or HIV-1 and HCV infection.