High frequency of gr/gr chromosome Y deletions in consecutive oligospermic ICSI candidates.

Background: The Y chromosome gr/gr microdeletion eliminates two copies of the DAZ gene and several additional transcriptional units and has been associated as a risk factor for infertility. Our objective was to study the presence of the gr/gr deletion in ICSI candidates in our population and to determine whether the laboratory, clinical and ICSI outcome were different in the gr/gr deleted patients.

Methods: Two hundred and eighty-three ICSI candidates were studied.