Publications by authors named "Maite Timmermans"
Background: How molecular profiles are associated with tumor microenvironment (TME) in high-grade serous ovarian cancer (HGSOC) is incompletely understood. Therefore, we analyzed the TME and molecular profiles of HGSOC and assessed their associations with overall survival (OS).
Methods: Patients with advanced-stage HGSOC treated in three Dutch hospitals between 2008-2015 were included.
Objective: Peritoneal metastases (PM) are a challenge in gynecological cancers, but its appearance has never been described in a population-based study. Therefore, we describe the incidence of PM and identify predictors that increase the probability of peritoneal spread.
Methods: All ovarian, endometrial and cervical cancer patients diagnosed in the Netherlands between 1989 and 2015 were identified from the Netherlands Cancer Registry and stratified for PM.
Article Synopsis
- A study in the Netherlands focused on advanced-stage ovarian cancer revealed that 14% of women diagnosed between 2008 and 2016 received no cancer-directed treatment.
- Factors such as age, higher FIGO stage, lower socioeconomic status, and co-morbidities were linked to a lack of treatment, with the trend increasing from 11% to 16% over the years.
- The primary reasons for not pursuing treatment were the patient's personal choice (40%) and their poor health condition (29%).
Article Synopsis
- * The age-adjusted incidence of BOTs increased from 2.1 to 4.2 per 100,000 person-years until 2011, then declined, while survival rates improved significantly over the same period.
- * The risk of developing a subsequent invasive ovarian carcinoma is low at 0.9%, with fewer patients receiving chemotherapy in recent years, reflecting changes in treatment practices and tumor classification.
Background: Patients with ovarian cancer who are diagnosed with Federation of Gynecology and Obstetrics (FIGO) stage IV disease are a highly heterogeneous group with possible survival differences. The FIGO staging system was therefore updated in 2014.
Objective: To evaluate the 2014 changes to FIGO stage IV ovarian cancer on overall survival.
Background: The scope of implementation research is often restricted to the analysis of organizations that participate voluntarily in implementation interventions. The recruitment of participants for a quality improvement collaborative increases awareness of the specific innovation. The objective of this multiphase observational study was to identify differences between organizations that participated in a large-scale implementation project aiming to improve perioperative care, functional recovery, and length of hospital stay after gynecologic surgery and organizations that did not participate.
View Article and Find Full Text PDFObjective: Surgical care for advanced stage epithelial ovarian cancer (EOC) patients has been centralized in the Netherlands since 2012. We evaluated whether the likelihood for patients to undergo surgery depends on the hospital of initial diagnosis before and after centralization of surgical care.
Methods: Patients with EOC FIGO stage IIB-IV, diagnosed in the Netherlands between 2000 and 2015, were identified from the Netherlands Cancer Registry.
Objective: The aim of this study was to compare surgical results and survival outcome of advanced ovarian cancer patients who were treated with primary versus interval debulking surgery.
Study Design: In this retrospective study stage III and IV ovarian cancer patients who received debulking surgery from 2006 to 2015 were included. Surgical results were described as complete, optimal or suboptimal debulking and chi-square test was used to assess significant differences.