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Publications by authors named "Maite T Tome-Esteban"

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Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.
Catherine W M Ong Paul T Elkington Sara Brilha Cesar Ugarte-Gil Maite T Tome-Esteban

PLoS Pathog

May 2015

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined.

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Synopsis of recent research by authors named "Maite T Tome-Esteban"

  • - Maite T Tome-Esteban's research primarily investigates the mechanisms that contribute to tissue destruction in pulmonary tuberculosis, focusing on the role of neutrophils and matrix metalloproteinases.
  • - One significant study titled "Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis" delineates how MMP-8, derived from neutrophils, influences matrix degradation, contributing to the cavitation observed in TB-infected lungs.
  • - The findings highlight the interplay between the immune response and tissue pathology in TB, suggesting that understanding these mechanisms could inform therapeutic strategies to mitigate lung damage in tuberculosis patients.

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