Publications by authors named "Maisa M Nakata"
J Control Release
October 2017
Article Synopsis
- Hepatocellular carcinoma (HCC) is a highly lethal cancer in the US, with a low 5-year survival rate (<20%), largely due to disease heterogeneity and inadequate treatments.
- Gene therapy research is advancing to tackle issues related to poor therapy responses and delivery challenges, particularly with non-viral strategies using biodegradable nanoparticles for targeted gene delivery.
- A specific PBAE nanoparticle formulation showed high transfection rates in various HCC cell lines without affecting healthy liver cells, demonstrating potential for effective and safe gene therapy in treating HCC.
