Exposure to depleted uranium does not alter the co-expression of HER-2/neu and p53 in breast cancer patients.

Background: Amongst the extensive literature on immunohistochemical profile of breast cancer, very little is found on populations exposed to a potential risk factor such as depleted uranium. This study looked at the immunohistochemical expression of HER-2/neu (c-erbB2) and p53 in different histological types of breast cancer found in the middle Euphrates region of Iraq, where the population has been exposed to high levels of depleted uranium.

Findings: The present investigation was performed over a period starting from September 2008 to April 2009.