Publications by authors named "Maire Kuddu"
Background: Changing patterns of alcohol and tobacco consumption and human papillomavirus (HPV) infection have affected the epidemiology of head and neck cancers. The aim of this study was to examine 20-year trends in the incidence and survival of head and neck cancers in Estonia by site, sex, morphology, and stage.
Methods: Data on all adult cases of invasive head and neck cancers diagnosed in Estonia in 1996-2016 were obtained from a population-based cancer registry.
The beneficial effects of protons are primarily based on reduction of low to intermediate radiation dose bath to normal tissue surrounding the radiotherapy target volume. Despite promise for reduced long-term toxicity, the percentage of cancer patients treated with proton therapy remains low. This is probably caused by technical improvements in planning and delivery of photon therapy, and by high cost, low availability and lack of high-level evidence on proton therapy.
View Article and Find Full Text PDFPurpose: To test the hypothesis that radiotherapy (RT) of head and neck squamous cell carcinoma (HNSCC) can be improved by hypoxic modification using nimorazole (NIM) in association with accelerated fractionation.
Materials And Methods: The protocol was activated in March 2012 as an international multicenter randomized trial in patients with HNSCC. Tumors were treated to a dose of 66-70Gy, 33-35 fractions, 6 fractions per week.
Article Synopsis
- This study investigates the effectiveness of accelerated fractionation radiotherapy for treating head and neck squamous-cell carcinoma (HNSCC) in areas with limited resources, following promising results from prior Western studies.
- Conducted from January 1999 to March 2004, the trial involved nearly 1,000 patients from various regions, comparing an accelerated treatment regimen of six sessions per week against a conventional five sessions per week.
- Results showed that both treatment groups received similar total radiation doses, with median treatment times differing, but the locoregional control rate after five years was noted to be 42% for patients receiving accelerated therapy.
Purpose: To assess resources and management strategies for the use of radiotherapy (RT) in the treatment of lung cancer in developing Central and Eastern European countries.
Materials/methods: Questionnaires on patterns of care of NSCLC and SCLC were sent to radiation oncologists of Central and Eastern Europe. Comparisons were made between two groups of countries-ex-USSR states and other Eastern and Central European countries.