Galenic approaches in troubleshooting of glibenclamide tablet adhesion in compression machine punches.

This study aimed to examine the adhesion of glibenclamide 5 mg tablets to the tools of compression machines. This problem is not commonly reported in the literature, since it is considered as tacit knowledge. The starting point was the implementation of three technical alternatives: changing the parameters of compression, evaluating the humidity of the powder blend and the manufacturer of the lubricant magnesium stearate.

Efavirenz dissolution enhancement I: co-micronization.

AIDS constitutes one of the most serious infectious diseases, representing a major public health priority. Efavirenz (EFV), one of the most widely used drugs for this pathology, belongs to the Class II of the Biopharmaceutics Classification System for drugs with very poor water solubility. To improve EFV's dissolution profile, changes can be made to the physical properties of the drug that do not lead to any accompanying molecular modifications.