Prevalence of rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan.

The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). This study was conducted to investigate the genetic association of the rs1260326 in NAFLD and T2DM in our population. NAFLD ( = 103), T2DM ( = 100), and control ( = 100) samples were collected and genotyped for rs1260326 by tetra-arm PCR.