Preparation of fused polycyclic vinylcyclopropanes via radical cascade reactions.

Radical cascades employing (dichloromethyl)dimethylsilyl ethers as both a point of radical initiation and termination, allow efficient entry to fused polycyclic cyclopropanes, and are also suitable for the design of other radical processes terminated by beta-elimination of chloride.

Synthesis and stereochemical confirmation of the secoiridoid glucosides nudiflosides D and A.

We describe herein an efficient access to the highly substituted cyclopentane unit present in the Nudifloside secoiridoid family via crotyl phosphonamide anion mediated conjugate addition to cyclopentenone.

PtCl2-catalyzed cycloisomerizations of 5-en-1-yn-3-ol systems.

5-En-1-yn-3-ol substrates bearing a free hydroxyl group or an acyl group are highly versatile partners for PtCl2-catalyzed cycloisomerizations. Electrophilic activation of the alkyne moiety triggers at wish a hydride or an O-acyl migration yielding at the end to regioisomeric keto derivatives. The efficient preparation of Sabina ketone, an important monoterpene precursor, has been worked out.

Two compression rods to treat unstable lesions of the pelvic ring.

The authors report 7 cases involving the surgical treatment of unstable pelvic ring fractures (Malgaigne type) using two compression bars, as described by Tile. The method was used only in cases where x-ray examination and CT scan revealed that the posterior branch of the fracture was located at the very medial aspect of the sacrum (fracture through the sacral foramina or even medial to the sacral foramina), and therefore could not be stabilized by using other devices.

Ketoprofen lysine salt inhibits disuse-induced osteopenia in a new non-traumatic immobilization model in the rat.

Immobilization and the consequent unloading can cause osteopenia both in humans and in animals due to an increased bone resorption and a parallel reduction in bone formation. Non-steroidal anti-inflammatory drugs (NSAIDs), and in particular the aryl propionic acids, are described to prevent bone loss by inhibiting the cyclo-oxygenase activity. In this study we evaluated the role of a classical aryl propionic acid, ketoprofen lysine salt (KLS), in a new model of disuse-induced osteoporosis in the rat.

Surgical treatment of pubic pain refractory to conservative treatment.

After some considerations on the biomechanical nature of pubic pain, the authors present a series of 17 leading athletes (14 professional football players, 1 marathon runner, 1 weight-lifter and 1 French boxer), complaining of this disorder for at least one year and refractory to conservative treatment, surgically treated with the Nesovic technique and evaluated after an average follow-up period of two years (18-30 months).

[The average thickness of trabecular osteons in the iliac crest in normal subjects].

The mean wall thickness (MWT), measured by the Kragstrup technique, and the trabecular bone volume (TBV), have been measured in 50 transiliac undecalcified bone biopsies performed in 50 subjects who died suddenly (traffic accident, carbon monoxide, poisoning). Diseases affecting the skeleton were excluded in the autopsies. Our values for MWT were similar to those found in previously published studies except those of Kragstrup's group, in which values are higher.

Evidence for a toxic effect of aluminum on osteoblasts: a histomorphometric study in hemodialysis patients with aplastic bone disease.

To evaluate the potential role of aluminum (Al) in a subset of dialysis patients with aplastic bone disease, we have studied tetracycline-labeled bone biopsies of 32 patients (22 males and 10 females, 45-73 years) on maintenance hemodialysis. Selection criteria included normal resorption surfaces (RS) and osteoid thickness. Eleven patients (Group I) had no stainable bone Al (Al-; 61.