Optical spectroscopy as a diagnostic tool for metal ion beam production with an ECRIS.

At GSI, the CAPRICE ECRIS is used to provide heavy ion beams to the UNILAC (Universal Linear Accelerator) accelerator. In order to satisfy the demand of metal ion beams, a resistively heated oven is routinely used. This evaporation technique allows the ion beam production from natural and enriched solid elements or compounds with high efficiency and low material consumption.

Genotype-phenotype correlation in FMF patients: A "non classic" recessive autosomal or "atypical" dominant autosomal inheritance?

Background: Uncertainty remains on the pathogenetic mechanisms, model of inheritance as well as genotype-phenotype correlation of FMF disease.

Objective: To investigate the impact of genetic factors on the FMF phenotype and the disease inheritance model.

Methods: A total of 107 FMF patients were enrolled.

Ion beam emittance from an ECRIS.

Simulation of ion beam extraction from an Electron Cyclotron Resonance Ion Source (ECRIS) is a fully 3 dimensional problem, even if the extraction geometry has cylindrical symmetry. Because of the strong magnetic flux density, not only the electrons are magnetized but also the Larmor radius of ions is much smaller than the geometrical dimension of the plasma chamber (Ø 64 × 179 mm). If we assume that the influence of collisions is small on the path of particles, we can do particle tracking through the plasma if the initial coordinates of particles are known.

Investigation of pulsed mode operation with the frequency tuned CAPRICE ECRIS.

In order to increase the intensity of the highly charged ions produced by the Electron Cyclotron Resonance Ion Sources (ECRISs), techniques like the frequency tuning and the afterglow mode have been developed and in this paper the effect on the ion production is shown for the first time when combining both techniques. Recent experimental results proved that the tuning of the operating frequency of the ECRIS is a promising technique to achieve higher ion currents of higher charge states. On the other hand, it is well known that the afterglow mode of the ECRIS operation can provide more intense pulsed ion beams in comparison with the continuous wave (cw) operation.

X-ray spectroscopy of warm and hot electron components in the CAPRICE source plasma at EIS testbench at GSI.

An experimental campaign aiming to detect X radiation emitted by the plasma of the CAPRICE source - operating at GSI, Darmstadt - has been carried out. Two different detectors (a SDD - Silicon Drift Detector and a HpGe - hyper-pure Germanium detector) have been used to characterize the warm (2-30 keV) and hot (30-500 keV) electrons in the plasma, collecting the emission intensity and the energy spectra for different pumping wave frequencies and then correlating them with the CSD of the extracted beam measured by means of a bending magnet. A plasma emissivity model has been used to extract the plasma density along the cone of sight of the SDD and HpGe detectors, which have been placed beyond specific collimators developed on purpose.

Investigations on the structure of the extracted ion beam from an electron cyclotron resonance ion source.

Using improved beam diagnostic tools, the structure of an ion beam extracted from an electron cyclotron resonance ion source (ECRIS) becomes visible. Especially viewing targets to display the beam profile and pepper pot devices for emittance measurements turned out to be very useful. On the contrary, diagnostic tools integrating over one space coordinate like wire harps for profile measurements or slit-slit devices, respectively slit-grid devices to measure the emittance might be applicable for beam transport investigations in a quadrupole channel, but are not very meaningful for investigations regarding the given ECRIS symmetry.

Operation of the CAPRICE electron cyclotron resonance ion source applying frequency tuning and double frequency heating.

The properties of the electromagnetic waves heating the electrons of the ECR ion sources (ECRIS) plasma affect the features of the extracted ion beams such as the emittance, the shape, and the current, in particular for higher charge states. The electron heating methods such as the frequency tuning effect and the double frequency heating are widely used for enhancing the performances of ECRIS or even for the routine operation during the beam production. In order to better investigate these effects the CAPRICE ECRIS has been operated using these techniques.

Influence of frequency tuning and double-frequency heating on ions extracted from an electron cyclotron resonance ion source.

The electromagnetic field within the plasma chamber of an electron cyclotron resonance ion source (ECRIS) and the properties of the plasma waves affect the plasma properties and ion beam production. We have experimentally investigated the "frequency tuning effect" and "double frequency heating" on the CAPRICE ECRIS device. A traveling wave tube amplifier, two microwave sweep generators, and a dedicated experimental set-up were used to carry out experiments in the 12.

Correction methods for organic carbon artifacts when using quartz-fiber filters in large particulate matter monitoring networks: the regression method and other options.

Sampling and handling artifacts can bias filter-based measurements of particulate organic carbon (OC). Several measurement-based methods for OC artifact reduction and/or estimation are currently used in research-grade field studies. OC frequently is not artifact-corrected in large routine sampling networks (e.

Emittance estimation by an ion optical element with variable focusing strength and a viewing target.

The emittance of an extracted ion beam can be estimated to first order by a series of three linear independent profile measurements. This estimation is restricted to the evaluation of an upper limit of the emittance value for a homogeneous, nonfilamented beam. The beam is assumed to be round, respectively elliptical, without any structure of the intensity distribution, no space charge has been assumed for the drifting beam, and the optics is assumed to be linear.

Review on high current 2.45 GHz electron cyclotron resonance sources (invited).

The suitable source for the production of intense beams for high power accelerators must obey to the request of high brightness, stability, and reliability. The 2.45 GHz off-resonance microwave discharge sources are the ideal device to generate the requested beams, as they produce multimilliampere beams of protons, deuterons, and monocharged ions, remaining stable for several weeks without maintenance.

Microwave to plasma coupling in electron cyclotron resonance and microwave ion sources (invited).

Coupling improvements between microwaves and plasmas are a key factor to design more powerful electron cyclotron resonance and microwave ion sources. On this purpose different activities have been undertaken by the INFN-LNS ion source team and a new approach was developed. Recent experiments confirmed the simulations, demonstrating that even in presence of a dense plasma, resonant modes are excited inside the cavity and the plasma dynamics depends on their structure.

SXT-related integrating conjugative element and IncC plasmids in Vibrio cholerae O1 strains in Eastern Africa.

Objectives: The objective of this study was to investigate the extent of resistance patterns and associated mobile genetic elements in epidemic V. cholerae O1 El Tor strains isolated from Eastern Africa in the late 1990s.

Methods: Self-transmissible genetic elements and associated clusters of genes encoding resistance were detected by conjugation experiments.

Cholera in Ethiopia in the 1990 s: epidemiologic patterns, clonal analysis, and antimicrobial resistance.

In 1993, after 6 years of absence, cholera re-emerged in the Horn of Africa. Following its introduction to Djibouti, the disease spread to the central and southern areas of Ethiopia reaching Somalia in 1994. Cholera outbreaks persisted in Ethiopia with a recrudescence of cases in 1998.

Clonal relationship among Vibrio cholerae O1 El Tor strains isolated in Somalia.

One hundred and three Vibrio cholerae O1 strains, selected to represent the cholera outbreaks which occurred in Somalia in 1998-1999, were characterized by random amplified polymorphic DNA patterns, ribotyping, and antimicrobial susceptibility. All strains showed a unique amplified DNA pattern and 2 closely related ribotypes (B5a and B8a), among which B5a was the more frequently identified. Ninety-one strains were resistant to ampicillin, chloramphenicol, spectinomycin, streptomycin, sulfamethoxazole, and trimethoprim, conferred, except for spectinomycin, by a conjugative plasmid IncC.

Observations of the frequency tuning effect in the 14 GHz CAPRICE ion source.

A set of measurements with the CAPRICE ion source at the GSI test bench has been carried out to investigate its behavior in terms of intensity and shape of the extracted beam when the microwaves generating the plasma sweep in a narrow range of frequency (+/-40 MHz) around the klystron center frequency (14.5 GHz). Remarkable variations have been observed depending on the source and the beamline operating parameters, confirming that a frequency dependent electromagnetic distribution is preserved even in the presence of plasma inside the source.

A status report of the multipurpose superconducting electron cyclotron resonance ion source.

Intense heavy ion beam production with electron cyclotron resonance (ECR) ion sources is a common requirement for many of the accelerators under construction in Europe and elsewhere. An average increase of about one order of magnitude per decade in the performance of ECR ion sources was obtained up to now since the time of pioneering experiment of R. Geller at CEA, Grenoble, and this trend is not deemed to get the saturation at least in the next decade, according to the increased availability of powerful magnets and microwave generators.

Microwave field distribution and electron cyclotron resonance heating process.

In an electron cyclotron resonance ion source, ions are produced from a plasma generated and sustained by microwaves with a proper frequency. Some experiments showed that the plasma formation, the consequent amount of particles extracted from the source, and the related beam shape strongly depend on the frequency of the electromagnetic wave feeding the cavity. In order to have a better understanding of these phenomena, in this work we deal with the description of the motion of a charged particle inside the plasma chamber model of the SERSE ion source operating at INFN-LNS in Catania, the analysis being applicable to any similar apparatus.

Energetics, skeletal dynamics, and long-term predictions on Kolmogorov-Lorenz systems.

We study a particular return map for a class of low-dimensional chaotic models called Kolmogorov-Lorenz systems, which received an elegant general Hamiltonian description and also includes the famous Lorenz-63 case, from the viewpoint of energy and Casimir balance. In particular, a subclass of these models is considered in detail, precisely those obtained from the Lorenz-63 by a small perturbation on the standard parameters, which includes, for example, the forced Palmer-Lorenz case. The paper is divided into two parts.

Clonal relationship among Vibrio cholerae O1 El Tor strains causing the largest cholera epidemic in Kenya in the late 1990s.

Eighty Vibrio cholerae O1 strains selected to represent the 1998-to-1999 history of the largest cholera epidemic in Kenya were characterized by ribotyping, antimicrobial susceptibility, and random amplified polymorphic DNA patterns. Except for 19 strains from 4 local outbreaks in North Eastern Province along the Somalia border, the other 61 strains from 25 outbreaks occurring in districts scattered around the country were all ribotype B27 and resistant to chloramphenicol, spectinomycin, streptomycin, sulfamethoxazole, and trimethoprim. The 61 strains showed similar and specific amplified DNA patterns.

Molecular epidemiology and origin of cholera reemergence in Italy and Albania in the 1990s.

In 1994 a cholera epidemic occurred in Italy and Albania after more than a decade of case absence. To investigate genotypic characteristics and the origin of the epidemic strains, 110 Vibrio cholerae O1 El Tor isolates from Italy and Albania were studied by randomly amplified polymorphic DNA analysis (RAPD), BglI ribotyping, and pulsed-field gel electrophoresis (PFGE) of genomic DNA. The Italian and Albanian strains were all ribotype 6 and their RAPD and PFGE patterns were identical as well.

Susceptibility to rifaximin of Vibrio cholerae strains from different geographical areas.

Four hundred and eight clinical strains of Vibrio cholerae isolated from different geographical areas and with different antimicrobial resistance patterns were tested for susceptibility to rifaximin, a non-absorbable antibiotic active in vitro against Gram-negative bacteria. The MICs ranged from 0.5 to 4 mg/l for all strains.

Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain.

Zonula occludens toxin (Zot) is an enterotoxin elaborated by Vibrio cholerae that increases intestinal permeability by interacting with a mammalian cell receptor with subsequent activation of intracellular signaling leading to the disassembly of the intercellular tight junctions. Zot localizes in the bacterial outer membrane of V. cholerae with subsequent cleavage and secretion of a carboxyl-terminal fragment in the host intestinal milieu.

A rapid method for restriction analysis of large plasmids from enteric pathogens.

A modified version of the method of Kado and Liu (J Bacteriol 1981, 145: 1365) has been developed for rapid detection and direct cleavage analysis of large plasmids from Vibrio cholerae and other enteric pathogens.

Vibrio cholerae in the horn of Africa: epidemiology, plasmids, tetracycline resistance gene amplification, and comparison between O1 and non-O1 strains.

The prevalence of Vibrio cholerae O1 and non-O1 has been investigated in numerous Somali regions of the Horn of Africa from 1983 to 1990. From January 1983 to January 1985 and between December 1986 and December 1990, no strains of V. cholerae O1 and 226 strains (5.