The present study investigated the expression of Toll-like receptor 4 (TLR4) and proteins involved in its associated signaling pathways in patients with classic Kaposi's sarcoma (KS) and acquired immune deficiency syndrome (AIDS)-associated KS (AIDS-KS) in Xinjiang Autonomous Region of China. A total of 35 patients with KS were enrolled in the present study between May 2011 and July 2013, including 26 cases of AIDS-KS and 9 cases of classic KS. Another 10 healthy subjects of the Uygur ethnic group were included in the normal control group.
View Article and Find Full Text PDFTo analyze the clinical features of AIDS-related Kaposi's sarcoma (AIDS-KS) patients in Xinjiang Autonomous Region and the impact of CD4 (+)T lymphocyte count, highly active antiretroviral therapy (HAART) and systemic chemotherapy on the prognosis. The clinical information of 80 AIDS-KS patients admitted in Sixth People's Hospital of Xinjiang Autonomous Region from January 2008 to August 2014 was retrospectively reviewed. Population characteristics, extent of lesions, KS progress, CD4 (+)T lymphocyte count, combined opportunistic infections, treatment and prognosis of these patients were analyzed.
View Article and Find Full Text PDFObjective: To summarize the major clinical features, treatment, follow-up and outcomes of acquired immune deficiency syndrome (AIDS) patients with prominent thrombocytopenia.
Methods: The manifestations, signs, anti-virus regimens, CD4 cell count, platelet count, prognosis and outcomes of 10 AIDS patients with prominent thrombocytopenia were collected and analyzed.
Results: After the administration of highly active antiretroviral therapy, platelet count and CD4 significantly improved during a follow-up period up to 12 months.