A qualitative study to examine meaningful change in physical function associated with weight-loss.

Purpose: This study explored perceptions of meaningful weight-loss and the level of change on two patient-reported outcome (PRO) measures, the 36-item Short Form Health Survey® [SF-36v2®] and Impact of Weight on Quality of Life Lite-Clinical Trials [IWQOL-Lite-CT], that individuals living with overweight or obesity consider to be meaningful and indicative of treatment success.

Methods: Thirty-three qualitative interviews were conducted in the US with adults living with overweight or obesity. Concept elicitation explored perceptions of minimally important/meaningful weight-loss using open-ended questions.