Publications by authors named "Maiko Sadamatsu"
Article Synopsis
- This study investigates the roles of caspase-8 and -9 in drug-induced liver injury (DILI) caused by CYP2E1 metabolites using rat models and human liver cell cultures exposed to carbon tetrachloride, halothane, and sevoflurane.
- In vivo results showed no liver dysfunction after sevoflurane exposure, but carbon tetrachloride and halothane led to increased liver damage indicators and caspase activities, indicating hepatotoxicity in both studies.
- CYP2E1-related compounds significantly contribute to the toxicity of halogenated hydrocarbons, suggesting that monitoring caspase-8 and -9 activities could serve as new
Carbon tetrachloride (CCl₄) facilitates the generation of hepatotoxins that can result in morphologic abnormalities, and these abnormalities are reasonably characteristic and reproducible for each particular toxin. It is also known that tumor necrosis factor-alpha (TNF-α) may participate in CCl₄-induced liver injury (CILI). In this study, we observed the chronological changes in circulating soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and -R2) in rats with CILI.
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