Publications by authors named "Maiko Kikuchi"
Article Synopsis
- Free-flap jejunal reconstruction after cervical esophagectomy is common in cervical esophageal cancer cases, but its use following gastric surgery had not been previously documented.
- The report details two cases of 75-year-old males with esophageal cancer who had undergone previous gastric surgeries and needed segmental esophagectomy with free-flap jejunal reconstruction.
- Both cases highlight the importance of careful preoperative planning and anatomical consideration due to the complexities introduced by prior gastric surgeries.
Objective: Treatment for borderline resectable (cT3br) esophageal squamous cell carcinoma (SCC) is currently undefined. This study aimed to analyze the outcome of treatment strategies including induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF) against T3br esophageal SCC.
Methods: A total of 32 patients with cT3br esophageal SCC enrolled in this study were treated with two cycles of DCF induction therapy.
Minimally invasive surgeries have been developed, not only for gastrointestinal cancer, but also for benign or emergency cases. We report the case of a 62-year-old male who underwent laparoscopic and thoracoscopic combined surgery for an esophago-mediastinal fistula caused by a press-through package. In the initial laparoscopic phase, transhiatal dissection of the lower thoracic esophagus and harvesting of the greater omentum were performed.
View Article and Find Full Text PDFBackground/aim: This study analyzed the outcomes of docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy and DCF plus concurrent radiotherapy (DCF-RT), both followed by conversion surgery, if possible, in patients with cT4b esophageal cancer.
Patients And Methods: Forty-six patients with cT4b esophageal cancer, including borderline cT4b lesions, were eligible. Borderline cT4b lesions were treated with induction DCF therapy.
Background: Anastomotic disorder of the reconstructed gastric conduit is a life-threating morbidity after thoracic esophagectomy. Although there are various reasons for anastomotic disorder, the present study focused on dislocation of the gastric conduit (DGC).
Methods: The study cohort comprised 149 patients who underwent transthoracic esophagectomy.
Background/aim: Plakophilin 1 (PKP1) expression is inversely related to cancer grade. This study aimed to evaluate whether PKP1 is a prognostic marker for esophageal cancer (EC).
Materials And Methods: We tested immunohistochemically for PKP1 in squamous cell carcinoma EC specimens from 99 patients, including cytoplasmic (C), membrane (M), and nuclear (N) cellular areas, and analyzed their relationships with clinicopathological factors.
Article Synopsis
- * Analysis of a cohort of 42 patients revealed a recurrence rate of 26.1%, with older age being a factor in recurrences; however, chemotherapy regimen type did not significantly influence outcomes.
- * Key findings suggest that poor nutritional status, indicated by factors like serum albumin and specific prognostic scores, correlates with worse disease-free survival and increased recurrence rates.
Background: This study aimed to examine the treatment outcomes of patients with brain metastases from esophageal cancer. Brain metastases from esophageal cancer are rare and have a poorer prognosis than brain metastases from lung and breast cancer.
Methods: This study included patients who were diagnosed with and treated for esophageal cancer in our department and subsequently developed brain metastases between April 2010 and December 2014.
A 41-year-old woman with type 3 advanced gastric cancer and Virchow lymph node, para-aortic lymph node, and multiple bone metastases was diagnosed with U-less cType 3 cT4aN3M1, cStage IV. We administered docetaxel, cisplatin, and S-1 (DCS)therapy for unresectable gastric cancer. After 11 courses of DCS, we confirmed that the distant lymph node metasta- ses were significantly reduced.
View Article and Find Full Text PDFObjective: Definitive chemoradiotherapy is useful for locally advanced esophageal cancer. However, salvage esophagectomy is required when residual or recurrent tumor is evident after chemoradiotherapy. We performed salvage esophagectomy combined with partial aortic wall resection after thoracic endovascular aortic repair for aortic invasion, and we evaluated the results.
View Article and Find Full Text PDFF-Fluorodeoxyglucose positron emission tomography (FDG-PET) is a useful imaging modality that reflects the tumor activity. However, FDG-PET is mainly used for advanced cancer, not superficial cancer. In this study, we investigated the relationship between the superficial tumor depth of esophageal cancer and the FDG uptake to determine the indications for endoscopic resection (ER).
View Article and Find Full Text PDFArticle Synopsis
- A Bochdalek hernia (BH) is a congenital diaphragmatic hernia that can manifest in adults, as shown in a case of a 26-year-old woman whose pregnancy triggered her symptoms.
- The woman experienced abdominal pain and difficulty breathing due to a left diaphragmatic hernia and successfully underwent laparoscopic surgery, showing no signs of recurrence after one year.
- Recent studies indicate that laparoscopic methods for treating adult BH are gaining popularity due to their safety and the absence of complications in cases reported from 1999 to 2016.
Background/aims: Because salvage surgery after definitive chemoradiotherapy for esophageal cancer is associated with high postoperative mortality and morbidity, minimally invasive methods are desirable. We analyzed the validity of minimally invasive salvage operations (MISO).
Methods: Twenty-five patients underwent salvage operation between 2010 and 2016 in our institution, 10 having undergone right transthoracic salvage esophagectomy (TTSE group), 6 transhiatal salvage esophagectomy (THSE), 6 salvage lymphadenectomy (SLA), and 3 salvage endoscopic submucosal dissection (SESD).
Background/aim: The purpose of this study was to identify adverse prognostic factors for patients with advanced esophageal cancer undergoing chemotherapy with docetaxel, cisplatin and 5-fluorouracil (DCF).
Patients And Methods: The study cohort comprised of 45 patients with advanced esophageal cancer who underwent induction DCF therapy followed by esophagectomy or chemoradiotherapy. Treatment outcomes and factors affecting early recurrence and death were analyzed.
Background/aim: Adequate mediastinal lymphadenectomy during thoracoscopic esophagectomy (TE) requires an extensive operating field. In order to rectify this problem, we developed slender tracheal forceps that can pass through a 12-mm trocar.
Patients And Methods: TE in the prone position was performed in 58 patients with esophageal cancer using slender tracheal forceps.
Background/aim: Esophageal squamous cell carcinoma (ESCC) is one of the most difficult malignancies to cure. C4d is a degradation product of the classical complement pathway and is suggested as an early diagnostic marker for other SCCs. The purpose of this study was to clarify the association of complement C4d with ESCC.
View Article and Find Full Text PDFBackground/aim: The purpose of the present study was to improve the diagnostic precision of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) after neoadjuvant chemotherapy (NAC) in patients with advanced esophageal cancer.
Patients And Methods: Thirty patients underwent FDG-PET/CT before and after NAC. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were measured.
A dose-escalation study of docetaxel (DOC), cisplatin (CDDP), and 5-fluorouracil (5-FU; DCF combination regimen) was performed to determine the maximum-tolerated dose (MTD), recommended dose (RD) and dose-limiting toxicities (DLT) in advanced esophageal carcinoma. Eighteen patients with esophageal carcinoma were enrolled and received DCF combination therapy at different dose levels. DLTs included febrile neutropenia and oral mucositis.
View Article and Find Full Text PDFArticle Synopsis
- Researchers observed needle-like structures, named mitochondrial fluorescent inclusion bodies (MFIBs), in stationary-phase Saccharomyces cerevisiae cultured with glucose, which were linked to elongated mitochondria.
- A specific protein identified as Ald4p, a mitochondrial aldehyde dehydrogenase, was found to be highly concentrated in MFIBs through 2D-gel electrophoresis and confirmed by immunofluorescence microscopy.
- The study indicates that MFIBs, containing Ald4p, are prevalent in the mitochondria of various yeast species, suggesting a common biological feature across these organisms.