Publications by authors named "Maiko Asai"
Incisional scarring is a factor of cosmetic appearance evaluated after breast reconstruction, along with the shape, position, and size of the breast. This study aimed to examine the effect of the incision scar location on patient satisfaction after breast reconstruction. Using the Japanese version of the SCAR-Q, we assessed the scar appearance, symptoms and psychosocial effects.
View Article and Find Full Text PDFObjective The current standard treatment for locally advanced, unresectable stage III non-small-cell lung cancer (NSCLC) is concurrent chemoradiation therapy (CCRT) and durvalumab administration. Although reports have indicated that the prognosis of squamous cell carcinoma is poorer than that of adenocarcinoma, real-world data are currently inadequate. Methods The present study analyzed patients with stage III NSCLC who received CCRT at the study center between April 2018 and February 2022.
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- The study examines the categorization of relapsed small cell lung cancer (SCLC) as "sensitive" or "refractory" based on outdated cutoff values for time between chemotherapy and disease progression, which may not apply to modern treatments.
- Researchers conducted a retrospective analysis involving patients treated before and after the approval of combination immunotherapy, identifying a new optimal cutoff value of 75 days for predicting overall survival.
- Findings indicate that this 75-day cutoff provides a more accurate prognosis for patients with relapsed SCLC compared to traditional 60 or 90-day values, especially in the context of immunotherapy advancements.
Article Synopsis
- - The study investigates whether regular blood tests are necessary for lung cancer patients receiving immune checkpoint inhibitors, specifically nivolumab or durvalumab.
- - A review of 201 medical records revealed 16 patients who received treatment without bi-weekly blood tests, focusing on potential adverse events.
- - Findings suggest that omitting blood tests did not lead to an increase in severe side effects, with issues detected through other methods instead.
Immuno-checkpoint inhibitor response and immune-related adverse events remain controversial issues. Managing pericardial effusion during programmed cell death 1 inhibitor treatment is challenging. Here, we report a case of successfully managed cardiac tamponade caused by nivolumab-induced pseudoprogression.
View Article and Find Full Text PDFBone marrow mesenchymal stromal cells (BM-MSCs) have been demonstrated to contribute to tissue regeneration. However, chronic pathological conditions, such as diabetes and aging, can result in a decreased number and/or quality of BM-MSCs. We therefore investigated the maintenance mechanism of BM-MSCs by studying signaling through the receptor for advanced glycation end products (RAGE), which is thought to be activated under various pathological conditions.
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