Determinants of pain interference and headache impact in patients who have chronic migraine with medication overuse: Results from the MOTS trial.

Objective: "Pain interference" and "headache impact" refer to negative consequences that pain and headache have on one's life. This study investigated determinants of these negative impacts in a large patient cohort who have chronic migraine with medication overuse.

Methods: Six hundred and eleven adults were enrolled from 34 headache, neurology, and primary care clinics.