Publications by authors named "Maike Paulino da Silva"
() is abundant within the microbial dysbiotic community of some patients with periodontitis. outer membrane protein 29 (OMP29), a member of the OMPA family, mediates the invasion of to gingival epithelial cells (GECs). This study evaluated the effect of OMP29 and its paralogue OMP29 on the response of GECs to .
View Article and Find Full Text PDFEffect of periodontal treatment on Aggregatibacter actinomycetemcomitans colonization and serum IgG levels against A. actinomycetemcomitans serotypes and Omp29 of aggressive periodontitis patients.
Oral Dis
March 2019
Article Synopsis
- The study aimed to assess how periodontal treatment affects the Aggregatibacter actinomycetemcomitans JP2 clone and serum IgG levels related to its outer membrane protein in patients with aggressive periodontitis.
- Seventeen generalized and ten localized aggressive periodontitis patients underwent scaling and root planing with antibiotics while their periodontal health was monitored over one year, noting improvements in probing depth and clinical attachment loss.
- Results showed significant reductions in IgG levels against specific serotypes and the JP2 clone, aligning their levels with those of healthy controls, indicating effective treatment outcomes.
The aim of this study was to evaluate the effects of monolaurin against (Aa) and determine their effects on the host transcriptome and metabolome, using an oral cell/bacteria co-culture dual-chamber model to mimic the human periodontium. For this, the Aa, was applied to cross the monolayer of epithelial keratinocytes (OBA-9) to reach the fibroblasts layer (HGF-1) in the basal chamber. The Monolaurin treatments (25 or 50 μM) were added immediately after the inoculation of the dual-chamber with Aa.
View Article and Find Full Text PDFBiomechanical analysis of engineered bone with anti-BMP2 antibody immobilized on different scaffolds.
J Biomed Mater Res B Appl Biomater
October 2016
Recently we have demonstrated the ability of monoclonal antibodies (mAb) specific for bone morphogenetic protein (BMP)-2 immobilized on different scaffolds to mediate bone formation, a process referred to as Antibody Mediated Osseous Regeneration (AMOR). One of the key properties of regenerated bone is its biomechanical strength, in particular in load-bearing areas. This study sought to test the hypothesis that the biomechanical strength of regenerated bone depends of the mode of regeneration, as well as the scaffold used.
View Article and Find Full Text PDFAggregatibacter actinomycetemcomitans is an important periodontal pathogen that can participate in periodontitis and other non-oral infections. The cytolethal distending toxin (Cdt) is among the virulence factors produced by this bacterium. The Cdt is also secreted by several mucosa-associated Gram-negative pathogens and may play a role in perpetuating the infection by modulating the immune response.
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