Publications by authors named "Maike GroSS"
The highly conserved Hsp90 chaperones control stability and activity of many essential signaling and regulatory proteins including many protein kinases, E3 ligases and transcription factors. Thereby, Hsp90s couple cellular homeostasis of the proteome to cell fate decisions. High-throughput mass spectrometry revealed 178 and 169 posttranslational modifications (PTMs) for human cytosolic Hsp90α and Hsp90β, but for only a few of the modifications the physiological consequences are investigated in some detail.
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- The study talks about how the balance of certain building blocks called dNTPs is super important for copying DNA correctly.
- Researchers looked for mutations in a gene (RNR1) in yeast that messed up this balance, finding 24 different types of mutations.
- Some of these mutations made it hard for the yeast to grow and made a lot of mistakes when copying DNA, especially when specific dNTPs were too high.