Fecal Calprotectin Test Performed at Home: A Prospective Study of Pediatric Patients With Inflammatory Bowel Disease.

Objectives: Measuring fecal calprotectin (FC) in a laboratory is time-consuming and that is why home tests have been developed. We studied the use of an FC home test in pediatric patients with inflammatory bowel disease (PIBD) in real-life settings.

Methods: The patients were asked to perform the IBDoc FC home test monthly for 6 months and to report their clinical disease activity at testing.

Long-term outcomes after elective ileocecal resection in children with active localized Crohn's disease--a multicenter European study.

Purpose: The aim of this study was to investigate the therapeutic role of an elective ileocecal resection in children with active localized Crohn's disease.

Methods: This was a retrospective multicenter study which included five European referral centers which included all children with Crohn's disease who underwent ileocecal surgery from 2000 to 2011 and had a minimum of 12 months follow-up.

Results: Altogether 68 patients fulfilled inclusion criteria.

Treatment of complex perianal fistulas with seton and infliximab in adolescents with Crohn's disease.

Background And Aims: Treatment of complex perianal fistulas associated with Crohn's disease is challenging. In adults, seton drainage combined with infliximab therapy has proven to be more effective than either one alone. Results following such treatment among pediatric patients have not been reported previously.

Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery.

Aim: To investigate whether matrix metalloproteinases-9 (MMP-9) or trypsinogens could serve as histological markers for an aggressive disease course in pediatric ulcerative colitis (UC).

Methods: We identified 24 patients with pediatric onset (≤ 16 years) UC who had undergone surgery during childhood/adolescence a median of 2.1 years (range 0.

Long-term outcomes after surgery on pediatric patients with Crohn disease.

Objective: Of pediatric patients with Crohn disease, 20% to 30% undergo surgery within 10 years. Although disease relapses and reoperations are common, long-term functional outcomes and quality of life (QoL) are unclear.

Methods: In 2010, we reviewed the hospital records of all pediatric patients with CD who had undergone intestinal resections during childhood in 2 major tertiary care hospitals between 1985 and 2008 and mailed out questionnaires that asked about health outcomes and QoL.

Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis.

Aim: To investigate matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pouch mucosa of pediatric onset ulcerative colitis (UC).

Methods: In this cross-sectional study, 28 patients with pediatric onset UC underwent ileal pouch biopsy 13 years (median) after proctocolectomy. Expression of MMPs-3, -7, -8, -9, -12 and -26 and TIMPs-1, -2 and -3 in samples was examined using immunohistochemichal methods, and another biopsy was used to evaluate the grade of histological inflammation.