Publications by authors named "Maiha Ando"
Article Synopsis
- The study investigates the role of the FcGR-IgG bond in macrophage phagocytosis and its potential for selective antigen discrimination, especially in mixed particle environments.
- Experimentation revealed that while an IgG-coated surface aids in the initial phagocytic process, non-coated particles can still be ingested if they are associated with opsonized ones.
- The findings suggest that while the zipper mechanism is important for starting phagocytosis, once it begins, it allows for unintended targets to be engulfed, which could have implications for both immune response research and medical applications.
The zipper model has been dominantly used to describe the driving mechanism of the engulfment process and its specific identification of antigens during phagocytosis in macrophages. However, the abilities and limitations of the zipper model, capturing the process as an irreversible reaction, have not been examined yet under the critical conditions of engulfment capacity. Here, we demonstrated the phagocytic behavior of macrophages after reaching the maximum engulfment capacity by tracking the progression of their membrane extension during engulfment using IgG-coated nondigestible polystyrene beads and glass microneedles.
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