[Role Of Emigration In The Spread Of HIV Infection In The Region Of Kayes, Mali].

Aim: To determine the impact of emigration on HIV transmission in the Kayes region.

Patients And Methods: It was a cross-sectional study conducted in 2007 in the Hospital of Kayes. A total of 109 subjects were included - all participants were over 14 years old and were diagnosed as HIV positive.

Occurrence, removal and accumulation in sludge of protozoan cysts and helminth eggs in a full-scale anaerobic pond in Burkina Faso.

The present paper investigates the occurrence, removal, and accumulation of protozoan cysts and helminth eggs in a large anaerobic pond treating municipal wastewater of Ouagadougou (Burkina Faso). With a hydraulic retention time of 6.5 days, the anaerobic pond achieved 100% removal of helminth eggs and protozoan cysts most of the time, except during the hot period.

Effects of ρ-Da1a a peptidic α(1) (A) -adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats.

Background And Purpose: ρ-Da1a, a 65 amino-acid peptide, has subnanomolar affinity and high selectivity for the human α(1) (A) -adrenoceptor subtype. The purpose of this study was to characterize the pharmacological effects of ρ-Da1a on prostatic function, both in vivo and in vitro.

Experimental Approach: ρ-Da1a was tested as an antagonist of adrenaline-induced effects on COS cells transfected with the human α(1) (A) -adrenoceptor as well as on human isolated prostatic adenoma obtained from patients suffering from benign prostatic hyperplasia.

Characterization of HIV-1 antiretroviral drug resistance after second-line treatment failure in Mali, a limited-resources setting.

Objectives: We describe the outcomes of second-line drug resistance profiles and predict the efficacy of drugs for third-line therapy in patients monitored without the benefit of plasma HIV-1 RNA viral load (VL) or resistance testing.

Methods: We recruited 106 HIV-1-infected patients after second-line treatment failure in Mali. VL was determined by the Abbott RealTime system and the resistance by the ViroSeq HIV-1 genotyping system.

Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.

Mutations in the connection domain (CD) of reverse transcriptase have been implicated in reverse transcriptase inhibitor (RTI) resistance, but this is controversial and little is known in non-B subtype HIV-1. We determined CD mutations prevalence in a population infected predominantly with CRF02_AG and investigated associations with phenotypic RTI resistance. Detected CD mutations were G335D (82.

Transmitted antiretroviral drug resistance in newly HIV-infected and untreated patients in Ségou and Bamako, Mali.

The WHO recommends regular surveillance for transmitted antiretroviral drug-resistant viruses in HIV antiretroviral treatment (ART)-naive patients in resource-limited settings. This study aimed to assess the prevalence of mutations associated with resistance in ART-naive patients newly diagnosed with HIV in Bamako and Ségou in Mali. HIV-positive patients who never received ART were recruited in Bamako and Ségou, Mali.

No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali.

Plasmodium falciparum resistance to artemisinins by delayed parasite clearance is present in Southeast Asia. Scant data on parasite clearance after artemisinins are available from Africa, where transmission is high, burden is greatest, and artemisinin use is being scaled up. Children 1-10 years of age with uncomplicated malaria were treated with 7 days of artesunate and followed for 28 days.

Effect of seasonality and ecological factors on the prevalence of the four malaria parasite species in northern mali.

Background. We performed 2 cross-sectional studies in Ménaka in the Northeastern Mali across 9 sites in different ecological settings: 4 sites have permanent ponds, 4 without ponds, and one (City of Ménaka) has a semipermanent pond. We enrolled 1328 subjects in May 2004 (hot dry season) and 1422 in February 2005 (cold dry season) after the rainy season.

Maternal and neonatal outcomes of grand multiparas over two decades in Mali.

Objective: To analyze the association between grand multiparity and maternal and neonatal morbidity and mortality.

Design: Retrospective cross-sectional study.

Setting: Point G National Hospital, a tertiary care hospital in Bamako, Mali.

Climate variability and environmental stress in the Sudan-Sahel zone of West Africa.

Environmental change in the Sudan-Sahel region of West Africa (SSWA) has been much debated since the droughts of the 1970s. In this article we assess climate variability and environmental stress in the region. Households in Senegal, Mali, Burkina Faso, Niger, and Nigeria were asked about climatic changes and their perceptions were compared across north-south and west-east rainfall gradients.

G protein-coupled receptors, an unexploited animal toxin targets: Exploration of green mamba venom for novel drug candidates active against adrenoceptors.

At a time when pharmaceutical companies are having trouble finding new low MW drugs and when biologics are becoming more common, animal venoms could constitute an underexploited source of novel drug candidates. We looked for identifying novel animal toxins active against G protein-coupled receptors (GPCR), the most frequently exploited class of treatment targets, with the aim to develop novel research tools and drug candidates. Screening of green mamba (Dendroaspis angusticeps) venom against adrenoceptors identified two novel venom peptides.

Pharmacological characterization of zinc and copper interaction with the human alpha(1A)-adrenoceptor.

Metal ions have a major role in human health, and interact with many classes of receptors including the G-protein coupled receptors. In the peripheral system, zinc mainly accumulates in the soft prostate organ and, with copper, influences prostate disease progression, from normal to hypertrophic or cancerous states. The development of these pathologies may be influenced by the α(1A)-adrenoceptor, the principal regulator of prostate tonicity.

[Small bowel obstruction and adhesions in general surgery at Gabriel Toure University Hospital].

Unlabelled: The objectives were to determine the frequency, to describe the clinical, therapeutic aspects and to evaluate the cost of the assumption of responsibility of occlusions by supports and or adherences. It was about a retrospective study carried out in the department of surgery general of the CHU Hôpital Gabriel TOURE from January 1st, 2002 to December 2008. Were included in this study all the patients operated for occlusion of hail on Brides and Adherence confirmed in per operational.

Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors.

BACKGROUND AND PURPOSE Muscarinic and adrenergic G protein-coupled receptors (GPCRs) are the targets of rare peptide toxins isolated from snake or cone snail venoms. We used a screen to identify novel toxins from Dendroaspis angusticeps targeting aminergic GPCRs. These toxins may offer new candidates for the development of new tools and drugs.

Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus.

Background: Data on community spread of methicillin-resistant coagulase-negative staphylococci (MR-CoNS) are scarce. We assessed their potential role as a reservoir of staphylococcal cassette chromosome mec (SCCmec) IVa, the leading SCCmec subtype in community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA).

Methods: Nasal carriage of MR-CoNS was prospectively investigated in 291 adults at hospital admission.

Sludge accumulation in an anaerobic pond and viability of helminth eggs: a case study in Burkina Faso.

Accumulation rates and pathogen concentrations in primary stabilization pond sludges in developing countries are important parameters for adequate sludge management and the safeguarding of public health with sludge reuse in agriculture. An anaerobic pond has been investigated for sludge accumulation rates and helminth egg viability after four years of operation in Burkina Faso. The rate of sludge accumulation was measured at 0.

[Osteomyelitis in sickle cell anemia patients in the Orthopedic and Trauma Department of the CHU Gabriel Toure].

Aim: Describe the severity of bone lesion and evaluate the results of the treatment of osteomyelitis in patients with sickle cell disease.

Material And Methods: It was about a prospective study done from December 2005 to November 2006 in patients with confirmed sickle cell admitted for osteomyelitis.

Results: We gather together 62 cases of osteomyelitis in sickle cell disease among 120 cases, which was about 51.

[Epidemiologic and therapeutic factors of postoperative incisional hernia at CHU Gabriel Touré].

Introduction: The incisional hernia is a frequent complication of the opened abdominal surgery. The objectives of this study were to determine the hospital frequency and the favoritizing factors, to analyze the therapeutic aspects.

Materials And Methods: We realized a retrospective study from January, 1999 to December, 2005 in the services of general and paediatric surgery of teaching hospital Gabriel Touré.

[Management of hand burns: clinical and epidemiological aspects and therapy at CHU Gabriel Toure].

Aim: Evaluate the care of burn sequel of the hand in the services of orthopaedic trauma and paediatric in the teaching hospital Gabriel Touré.

Methods: It was about a longitudinal and prospective study lasting from Jun 2006 to January 2008 in all the children aged from 0 to 14 years with burn sequel of the hand admitted and treated in the services of orthopaedic- trauma and paediatric surgery of Gabriel Touré. Patients with an incomplete file or lost during the study were not included.

[Omphalocele in general and pediatric surgery in Gabriel Touré].

Introduction: the omphalocèle is an evolution of the extra embryonic coulombs between the 32th and the 72th days of the pregnancy. The treatment depends on his volume. In Mali; few works were published on the omphalocèle and its treatment.

[Pharmacovigilance and impact of intermittent preventive treatment with sulfadoxine-pyrimethamine in pregnant women in Sélingué, Mali].

This study aimed to evaluate the impact of intermittent preventive treatment (IPT) and the associated adverse effects in pregnant women living in hyperendemic area of Sélingué in Mali on pregnancy outcome. Pharmacovigilance aims, monitoring the risk of adverse effects resulting from the use of drugs and products for human use licensees of marketing. IPT with sulfadoxine-pyrimethamine (SP) is based on the administration of 2 doses of SP treatment in pregnant women at defined intervals after about 18-20 weeks of pregnancy.

[Major cardiovascular risk factors according to gender in the hospital environment].

Aim: The study aims to describe cardiovascular risk factor according to gender in hospital.

Material And Methods: Il was a prospective study from april 2007 to march 2008 including 146 highblood pressure patients from 2 medical centre in Bamako. Gathering and analysis were performed with SPSS 11.

Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor.

Background And Purpose: Venoms are a rich source of ligands for ion channels, but very little is known about their capacity to modulate G-protein coupled receptor (GPCR) activity. We developed a strategy to identify novel toxins targeting GPCRs.

Experimental Approach: We studied the interactions of mamba venom fractions with alpha(1)-adrenoceptors in binding experiments with (3)H-prazosin.

Resistance-associated mutations to etravirine (TMC-125) in antiretroviral-naïve patients infected with non-B HIV-1 subtypes.

Susceptibility to etravirine (ETR), an expanded-spectrum nonnucleoside reverse transcriptase inhibitor (NNRTI), is dependent on the type and number of NNRTI resistance-associated mutations (RAMs). Studies have shown that some HIV-1 subtypes may have natural polymorphisms described as ETR RAMs. This study addresses the prevalence of ETR RAMs in treatment-naïve patients infected with HIV-1 non-B subtypes and its potential impact on ETR susceptibility.

Evaluation of immunization coverage within the Expanded Program on Immunization in Kita Circle, Mali: a cross-sectional survey.

Background: In 1986, the Government of Mali launched its Expanded Program on Immunization (EPI) with the goal of vaccinating, within five years, 80% of all children under the age of five against six target diseases: diphtheria, tetanus, pertussis, poliomyelitis, tuberculosis, and measles. The Demographic and Health Survey carried out in 2001 revealed that, in Kita Circle, in the Kayes region, only 13% of children aged 12 to 23 months had received all the EPI vaccinations. A priority program was implemented in 2003 by the Regional Health Department in Kayes to improve EPI immunization coverage in this area.