[Structural and Functional Remodeling of Vascular Wall in Persons With Family History of Hypertension].

Aim of investigation - to study parameters of structural and functional remodeling of vascular wall in persons with family history of hypertension (with burdened or positive hypertensive heredity). We examined 95 persons (aged 17 - 28 years) with family history of hypertension (positive hypertensive heredity) and divided them into 3 groups: group 1 - patients with arterial hypertension (AH), group 2 - patients with high normal blood pressure (BP), group 3 - persons with normal BP). Control (C) group comprised 24 subjects with normal BP without family history of AH.

[Pharmacogenomic control of angiotensin converting enzyme gene I/D polymorphism predominant risk factor of development of chronic heart failure and target of enalapril treatment].

Aim of investigation - to study effect of angiotensin-converting enzyme (ACE) gene polymorphism as a dominant risk factor of development of chronic heart failure (CHF) and target for effective therapy with ACE inhibitor enalapril in patients with ischemic heart disease. We followed 226 patients with CHF on stable permanent basic therapy comprising -adrenoblocker, diuretic, aldosterone antagonist, digoxin, and ACE inhibitor. Seventy eight patients received enalapril (starting dose 2.

[Impact of angiotensionogen and angiotensin II receptor type 1 gene polymorphisms on the development and course of chronic heart failure].

Aim: To study the impact of angiotensinogen (AGT) and angiotensin II receptor type 1 (AGTR1) gene polymorphisms on the development and course of chronic heart failure (CHF) in patients with coronary heart disease (CHD).

Subjects And Methods: Two hundred and twenty-six patients (149 men and 77 women; mean age 55.9 +/- 5.

[Rational minimally invasive nature in surgical reconstructions of the abdominal aorta].

Based on a meta-analysis of the literature and own experience in a total of 490 reconstructions of the aortofemoral segment using a miniapproach, the authors carried out a comparative analysis of the main minimally invasive methods employed for treatment of the pathology concerned.

[Outcomes of using autologous peripheral-blood stem cells in patients with chronic lower arterial insufficiency].

Presented herein are the outcomes of using autologous peripheral blood stem cells (SCs) in patients with stage II В lower limb chronic obliterating diseases (according to A.V. Pokrovsky's classification).

[Polymorphism of eNOS and iNOS Genes and Chronic Heart Failure in Patients With Ischemic Heart Disease].

Unlabelled: URGENCY: Despite substantial progress in the treatment of coronary heart disease (CHD) and chronic heart failure (CHF) prognosis in these conditions remains extremely serious. This warrants their timely prevention and early detection. Aim.

[Impact of Gly389Arg beta1-adrenoceptor polymorphism on the risk of chronic heart failure, the nature of its course, and on the efficiency of its treatment with carvedilol].

Aim: To study beta1-adrenoceptor gene (ADRB1) polymorphism on the development and course of chronic heart failure (CHF) and on the efficiency of its treatment with the beta-adrenoblocker carvedilol in patients with coronary heart failure.

Subjects And Methods: Two hundred and twenty-six patients (149 males and 77 females; mean age 55.9 +/- 5.

[Immunomodulating, metabolic and cardioprotective effects of AT1-angiotensin receptors blocker losartan in patients with coronary heart disease and type 2 diabetes mellitus].

Aim: To evaluate effects of 6-month therapy with losartan in combination with indapamide on a clinical course, immunological, metabolic parameters, left ventricular function, exercise tolerance and quality of life in patients with coronary heart disease (CHD) associated with metabolic syndrome (MS).

Material And Methods: Forty six CHD patients with postinfarction cardiac dysfunction in MS were randomized into two groups. Group 1 consisted of 22 patients with impaired glucose tolerance, group 2--of 24 type 2 diabetics.

[Characteristics of systemic inflammatory reaction in elderly patients of different age with the chronic heart failure].

The peculiarities of development systemic inflammatory reactions during the chronic heart failure were studied in the research. The patients with different severity of the chronic heart failure and different clinical course were examined at the beginning and in the dynamics of the clinical observation. The functional activity of neutrophils, pro- and antioxidant activity of serum were estimated in these patients.

[Use of zeolite-containing biologically active food supplement in patients with burn trauma].

The content of cationic protein in blood neutrophils, the serum activity of lysosomal enzymes, the intensity of peroxide lipid oxidation, the antioxidant serum activity and the blood concentration of trace elements were assessed in patients with burn injury. Some patients as addition to the main therapy got zeolyt-containing biological active addition to food (BAAF) "Lytovit" with its ability for sorption and selective ion exchange. Before the beginning of the treatment in all patients high value of the cationic protein degranulation, decrease of neutrophils biocidity, and increase of lipid peroxidation against a background of antioxidant activity were found.

[The determination of the leukocyte-modulating activity of the blood serum in an acute coronary syndrome].

A method for evaluating the serum leukocyte-modulating activity (LMA) in patients with unstable angina pectoris (UAP) and acute myocardial infarction (AMI) is proposed. The method consists in measuring the total phlogogenic potential of the blood serum from increase or decrease in the chemiluminescence of donor leukocyte suspension after its incubation with patient's serum. LMA sufficiently accurately reflects the imbalance between the pro- and anti-inflammatory activities of the serum in patients with UAP and AMI.

[Trimetazidine effects on exercise tolerance and left ventricular diastolic function in patients with coronary heart disease].

Aim: Trial of trimetasidine effects on exercise tolerance (ET) and left ventricular diastolic function (LVDF) in patients with coronary heart disease (CHD).

Materials And Methods: The study group included 40 CHD patients. Of them 10, 18 and 12 had myocardial infarction, unstable angina pectoris and stable angina, respectively.

[The diagnostic and prognostic assessment of the changes in lysosomal enzymatic activity in the blood of patients with acute myocardial infarct and unstable stenocardia].

Serum activity of five lysosomal marker enzymes was measured in patients with acute myocardial infarction (AMI) and unstable angina pectoris (UAP) with consideration of the disease severity. A significant increase of enzyme activity was found both in patients with UAP and AMI on the first day of hospitalization. The enzymes activity was higher in patients with more severe form of AMI.

[Various mechanisms of lysosome involvement in the process of tissue injury].

Impairments in structural integrity of liver, heart and skeletal muscle lysosomes followed by necrotic and necrobiotic alterations in the tissues and secretion of active hydrolases in blood were detected under conditions of exhaustive physical exercises in rats when dose-dependent physical loading was studied. At the same time, in patients with hypertrophic cardiomyopathy physical loading, carried out as stepwise spiroveloergometry up to the submaximal heart rate, led to release of lysosomal enzymes into blood, which was not observed in healthy persons under similar conditions. The higher level of enzymes was found in circulation of the patients with most severe forms of the disease.