Publications by authors named "Maia G Clare"
Article Synopsis
- Th9 cells produce IL-9 and differentiate from naïve T cells using signals from cytokines like IL-4, TGF-β, and IL-2, particularly in inflamed tissues.
- The study reveals that in conditions with limited IL-2, Th9 cells show lower IL-9 production and reduced NF-kB activation, indicating that IL-2 is crucial for their optimal function.
- Additionally, introducing IL-1β can enhance Th9 differentiation by activating NF-kB and suppressing the inhibitory factor BCL6, thus improving the cells' response even when IL-2 is low.
IL-9-producing Th cells, termed Th9 cells, contribute to immunity against parasites and cancers but have detrimental roles in allergic disease and colitis. Th9 cells differentiate in response to IL-4 and TGF-β, but these signals are insufficient to drive Th9 differentiation in the absence of IL-2. IL-2-induced STAT5 activation is required for chromatin accessibility within enhancer and promoter regions and directly transactivates the locus.
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