Autoimmune Regulator Gene Polymorphisms in Egyptian Systemic Lupus Erythematosus Patients: Preliminary Results.

Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease. The autoimmune regulator () is a master regulator of self-tolerance development. mutations lead to the development of autoimmune polyglandular syndrome type 1 while polymorphisms have been linked to organ-specific autoimmunity.

Superiority of rectal snip over serology in detection of schistosomiasis eradication: A pilot study.

Background And Study Aims: The diagnosis of schistosomiasis is based on serological determination of anti-schistosoma antibody and schistosoma antigen in serum and urine but the gold standard test is the microscopic detection of schistosoma eggs in urine and stool. However, there is an urgent demand to reach the elimination goal with higher sensitivity and specificity tools. This study aimed to evaluate the sensitivity and specificity of anti-schistosoma antibody and schistosoma antigen in comparaison with rectal snip in the detection and prediction of eradication of schistosomiasis in previously and/or incidentaly diagnosed patients.

Outcomes of patients with Severe Acute Respiratory Infections (SARI) admitted to the intensive care unit: results from the Egyptian Surveillance Study 2010-2014.

Background: Few data exist about respiratory viral infections in Egyptian patients. Hereby we describe the outcomes of hospitalized Egyptian patients with severe acute respiratory infections (SARI) admitted to the ICU.

Methods: A prospective study in which all hospitalized patients meeting the WHO case definition for SARI and admitted to the ICU, during the period 2010-2014, were enrolled.

Tumor necrosis factor gene expression in regular hemodialysis patients.

This study evaluates tumor necrosis factor (TNF)-alfa gene expression in patients with end-stage renal disease (ESRD) on regular hemodialysis as an expression of cardiovascular disease (CVD) risk even on a sub-clinical level and its relation to some of the parameters incriminated in the pathogenesis and the establishment of uremic arteriopathy. A total of 51 patients with ESRD on regular hemodialysis and 20 healthy subjects matching in age and gender as a control group were recruited. All selected cases were subjected to serum lipid profile, Creactive protein (CRP), TNF-alfa gene expression and Doppler study of carotid arteries to estimate carotid intimal media thickness (cIMT).

Intrafamilial transmission of hepatitis C infection in Egyptian multitransfused thalassemia patients.

Objective: Detecting the current prevalence of hepatitis C virus (HCV) among Egyptian multitransfused thalassemic patients and evaluating the risk of its transmission within their family members.

Methods: Multitransfused Egyptian thalassemia patients (n = 137) were tested for HCV infection. Household contacts of positive members were compared with household contacts of HCV-negative patients.

Noninvasive assessment of hepatic fibrosis and necroinflammatory activity in Egyptian children with chronic hepatitis C virus infection using FibroTest and ActiTest.

Background: Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatic fibrosis. Liver biopsy, because of its limitations and risks, might be considered an imperfect gold standard for assessing the severity of chronic liver diseases. In this study, we aimed to prospectively validate FibroTest (FT) and ActiTest (AT) as noninvasive serum biochemical markers for assessment of the degree of hepatic fibrosis and necroinflammatory activity respectively, in pediatric patients with chronic HCV infection and compare them to liver biopsy.