Publications by authors named "Mai Sasaki Aanensen Fraz"
Extrapulmonary infections with are rare, but important to acknowledge. We report a case of infective endocarditis (IE) with in a 66-year-old immunocompetent man with an aortic homograft. The diagnosis was made by direct 16S rRNA gene amplification from valve material, confirmed by a targeted -PCR in serum and the detection of specific antibodies.
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- About 20-30% of patients with common variable immunodeficiency (CVID) develop a lung disease called granulomatous-lymphocytic interstitial lung disease (GLILD), which complicates their condition.
- The study aimed to identify specific serum biomarkers that can differentiate GLILD from other non-infectious complications in CVID.
- Findings showed that GLILD patients had elevated markers indicating T cell activation, lung tissue damage, and extracellular matrix remodeling, suggesting important pathways for treatment and potential clinical biomarkers for patient evaluation.
Unlabelled: Common variable immunodeficiency (CVID) is characterized not only by recurrent bacterial infections, but also autoimmune and inflammatory complications including interstitial lung disease (ILD), referred to as granulomatous-lymphocytic interstitial lung disease (GLILD). Some patients with GLILD have waxing and waning radiologic findings, but preserved pulmonary function, while others progress to end-stage respiratory failure. We reviewed 32 patients with radiological features of GLILD from our Norwegian cohort of CVID patients, including four patients with possible monogenic defects.
View Article and Find Full Text PDFBackground: The pathogenesis of coronavirus disease 2019 (COVID-19) is still incompletely understood, but it seems to involve immune activation and immune dysregulation.
Objective: We examined the parameters of activation of different leukocyte subsets in COVID-19-infected patients in relation to disease severity.
Methods: We analyzed plasma levels of myeloperoxidase (a marker of neutrophil activation), soluble (s) CD25 (sCD25) and soluble T-cell immunoglobulin mucin domain-3 (sTIM-3) (markers of T-cell activation and exhaustion), and sCD14 and sCD163 (markers of monocyte/macrophage activation) in 39 COVID-19-infected patients at hospital admission and 2 additional times during the first 10 days in relation to their need for intensive care unit (ICU) treatment.