Publications by authors named "Mai Ohuchi"
Recent studies reveal that biosynthesis of iron-sulfur clusters (Fe-Ss) is essential for cell proliferation, including that of cancer cells. Nonetheless, it remains unclear how Fe-S biosynthesis functions in cell proliferation/survival. Here, we report that proper Fe-S biosynthesis is essential to prevent cellular senescence, apoptosis, or ferroptosis, depending on cell context.
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- Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme in NAD biosynthesis that presents a promising target for cancer treatment, particularly in neuroendocrine tumors like lung and prostate cancer.
- Neuroendocrine tumors show a particular vulnerability to NAMPT inhibitors (NAMPTi), which is further enhanced by dietary changes that affect NAD synthesis pathways.
- Circulating nicotinic acid riboside (NAR) can decrease the effectiveness of NAMPT inhibitors, but reducing NAR levels in combination with NAMPTi treatment proves to be effective in killing tumor cells in mouse models.