A study on male Wistar rats examined the impact of continuous light exposure (CL) and a western diet (WD) on the expression of Adropin, RORα, and Rev-erb-α, as well as energy balance over three months.
Findings revealed that CL alone boosted Adropin levels and gene expression, while WD and its combination with CL reversed these effects and altered gene expressions related to energy metabolism.
The combination of CL and WD not only increased total energy expenditure but also led to a reduction in food intake and multiple degenerative effects on liver, spleen, and kidney tissues, highlighting the negative implications for energy homeostasis.