Identification of Antiviral Compounds against Monkeypox Virus Profilin-like Protein A42R from .

Infections caused by the monkeypox virus (MPXV) have continued to be transmitted significantly in recent years. However, understanding the transmission mechanism, risk factors, and consequences of infection are still limited. Structure-based drug design for MPXV is at an early stage due to the availability of protein structures that have been determined experimentally.

Discovery of Small Molecules from Targeting RNA-Dependent RNA Polymerase of Japanese Encephalitis Virus.

The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes viral encephalitis leading to neural damage, is a major threat in most Asian countries. The RNA-dependent RNA polymerase (RdRp) present in the viral genome is the key component for genome replication, making it an attractive target for antiviral drug development. In this study, the natural products from were retrieved for structure-based virtual screening against JEV-RdRp.