Publications by authors named "Mai Lieu"
Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice.
Int J Neuropsychopharmacol
October 2014
Article Synopsis
- Drinking alcohol repeatedly can make mice want to drink even more later on, and scientists are trying to figure out why.
- They experimented with mice by giving them alcohol and different drugs to see how their drinking changed over time.
- The findings suggest that certain changes in the DNA and genes related to alcohol response are important for understanding how these behaviors develop.
Article Synopsis
- The NR2B gene is linked to addiction and its expression increases when someone has a lot of alcohol and then stops drinking.
- This study looked at how using and then stopping alcohol affects certain changes in histone modifications (which help control genes) related to the NR2B gene.
- The researchers found that after stopping alcohol, a special change in histones happened that could help explain how alcohol affects the brain's response to addiction.