The impact of sleep-wake problems on health-related quality of life among Japanese nursing college students: a cross sectional survey.

Aim: This study was conducted to examine the impact of sleep-wake problems on health-related quality of life of Japanese nursing college students.  METHODS: This cross-sectional study was conducted in 2019 on 150 third and fourth-year nursing college students from two locations in Japan. Insomnia severity was assessed using the Insomnia Severity Index (ISI) and health-related quality of life using the SF-8 questionnaire.

A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster.

Background: Several lines of evidence associate misregulated genetic expression with risk factors for diabetes, Alzheimer's, and other diseases that sporadically develop in healthy adults with no background of hereditary disorders. Thus, we are interested in genes that may be expressed normally through parts of an individual's life, but can cause physiological defects and disease when misexpressed in adulthood.

Results: We attempted to identify these genes in a model organism by arbitrarily misexpressing specific genes in adult Drosophila melanogaster, using 14,133 Gene Search lines.