Publications by authors named "Mahvash Jebeli"
Article Synopsis
- Calcific aortic valve disease (CAVD) is a prevalent heart valve condition in older populations, with two main pathways: osteogenic and dystrophic; the latter is more common.
- The study aims to develop a new 3D dystrophic calcification model that reflects cell interactions better than existing 2D models and shows that programmed cell death (apoptosis) is crucial for calcification.
- By using porcine valvular interstitial cell spheroids, researchers found that inhibiting apoptosis reduced calcification, and the addition of antioxidants (like ascorbic acid) further decreased calcification, indicating the importance of extracellular matrix production and oxidative stress in this process.
Mechanical stress patterns emerging from collective cell behavior have been shown to play critical roles in morphogenesis, tissue repair, and cancer metastasis. In our previous work, we constrained valvular interstitial cell (VIC) monolayers on circular protein islands to study emergent behavior in a controlled manner and demonstrated that the general patterns of cell alignment, size, and apoptosis correlate with predicted mechanical stress fields if radially increasing stiffness or contractility are used in the computational models. However, these radially symmetric models did not predict the existence of local regions of dense aligned cells observed in seemingly random locations of individual aggregates.
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