Publications by authors named "Mahshid Safavi"
Article Synopsis
- HTLV-1 is associated with serious diseases like adult T-cell leukemia/lymphoma and tropical spastic paraparesis, and understanding its prevalence in areas like Alborz province, Iran, is crucial.
- The study focused on the genetic analysis of the virus, particularly the highly conserved long terminal repeat (LTR) region and the Tax oncoprotein, to understand its phylogenetic relationships.
- Among about 15,000 blood donors, only 19 tested positive for HTLV-1, showing a 0.13% positivity rate, with the virus identified as subtype A; while mutations were present, they did not significantly impact the virus's functions or virulence.
COVID-19 is primarily classified as a respiratory disorder; however, various neurological symptoms have been reported in COVID-19 patients. Neurological manifestations may be the initial signs of COVID-19 and can develop in patients of different age groups and with or without underlying disease. COVID-19 causes a broad range of complications in the central nervous system.
View Article and Find Full Text PDFCOVID-19 and coronary artery disease; A systematic review and meta-analysis.
New Microbes New Infect
June 2023
Background And Aim: Patients with underlying cardiovascular disorders such as coronary artery disease (CAD) are more prone to severe forms and multiple complications of COVID-19. The present systematic review and meta-analysis aimed to investigate the impact of CAD on patients with COVID-19.
Methods: Main electronic databases, including Medline (via PubMed), EMBASE, and Web of Science, were carefully searched and reviewed for original research articles published between 2019 and 2021.
Article Synopsis
- The study investigates the expression of CNR1 and CNR2 genes, which are part of the endocannabinoid system, in COVID-19 patients with and without diabetes to understand their potential role in the disease.* -
- Researchers isolated peripheral blood monocytes from eight groups (including COVID-19 patients, diabetics, and healthy individuals) and used real-time PCR to analyze gene expression levels.* -
- Findings showed that CNR1 and CNR2 gene expression was significantly higher in severe and moderate COVID-19 patients compared to healthy controls, suggesting a potential link between the endocannabinoid system and COVID-19 severity.*
Molecular epidemiology and phylogenetic analysis of human T-lymphotropic virus type 1 in the gene and it association with adult t-cell leukemia/lymphoma disorders.
Iran J Microbiol
August 2021
Background And Objectives: Human T-lymphotropic virus type-1 (HTLV-1) belongs to retrovirus family that causes the neurological disorder HTLV-1 adult T-cell leukemia/lymphoma (ATLL). Since 1980, seven subtypes of the virus have been recognized. HTLV-1 is prevalent and endemic in some regions, such as Africa, Japan, South America and Iran as the endemic regions of the HTLV-1 in the Middle East.
View Article and Find Full Text PDFIntroduction: Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021.
View Article and Find Full Text PDFBackground And Aim: The global rise of antimicrobial resistance among bacterial strains is a rapidly growing challenge and is becoming a major public health concern. This study documents the worldwide spread and genotype distribution of human clinical isolates of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae (NPKP).
Methods: Several international databases, including Web of Science, Embase and Medline were searched (2010 - 2019) to identify studies addressing the frequency of NPKP regionally or worldwide.