Publications by authors named "Mahshad Pourgholi"
Article Synopsis
- This study investigates the protective effects of hesperidin on female mice with chronic lymphocytic leukemia induced by n-ethyl-n-nitrosourea (ENU).
- Mice were treated with hesperidin for 30 days before being given ENU, and their weight and mortality were monitored over 120 days.
- Results showed that hesperidin significantly increased survival rates (up to 86%), delayed death, and improved various cellular toxicity markers, suggesting that hesperidin may help counteract the toxic effects of certain carcinogens.
Alkylating agents such as N-Ethyl-N-Nitrosourea (ENU) are ubiquitous within living cells and in the environment. This study designed to evaluate the chemopreventive activity of vanillic acid on ENU-induced toxicity and carcinogenesis in mice as an animal model of chronic lymphocytic leukemia (CLL). The female, Swiss albino mice were divided into three groups each with 7 mice, group I received normal saline, group II, mice received ENU at a dose of 80 mg/kg body weight i.
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